sup-17 Antibody

Datasheet

Code	CSB-PA187324XA01CXY
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Product Details
Customer Reviews and Q&A
Target Background

Product Details

Full Product Name

Rabbit anti-Caenorhabditis elegans sup-17 Polyclonal antibody

Uniprot No.

G5EFD9

Target Names

sup-17

Alternative Names

sup-17 antibody; DY3.7Disintegrin and metalloproteinase domain-containing protein 10 homolog antibody; ADAM 10 homolog antibody; EC 3.4.24.81 antibody

Raised in

Rabbit

Species Reactivity

Caenorhabditis elegans

Immunogen

Recombinant Caenorhabditis elegans sup-17 protein

Immunogen Species

Caenorhabditis elegans

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB (ensure identification of antigen)

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Value-added Deliverables

① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);

Quality Guarantee

① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;

Lead Time

Made-to-order (14-16 weeks)

Customer Reviews and Q&A

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Target Background

Function

Metalloprotease. Acts together with protease adm-4 and in a cell autonomous manner to facilitate lin-12/Notch signaling during developmental cell fate decision, including anchor cell/ventral uterine precursor cell decision and vulva precursor cell specification. By modulating glp-1/Notch signaling, plays a role in germline development. Probably by modulating BMP-like Sma/Mab signaling via the shedding of unc-40 ectodomain, involved in the regulation of body size and mesoderm development. Probably by shedding ephrin efn-4, regulates axon guidance of SDQL neuron during development.

Gene References into Functions

SUP-17 functions to promote BMP signaling. SUP-17 binds TSP-12. Substrates of SUP-17 in the BMP signaling pathway is UNC-40. PMID: 28068334
Sup-17 and adm-4 are functionally redundant for at least a subset of LIN-12/Notch-mediated cell fate decisions in C. elegans. PMID: 16197940

Subcellular Location

Cell membrane; Single-pass type I membrane protein. Basolateral cell membrane; Single-pass type I membrane protein. Cytoplasmic vesicle membrane; Single-pass type I membrane protein.

Tissue Specificity

Expressed in the germline.

Database Links

KEGG: cel:CELE_DY3.7

STRING: 6239.DY3.7

UniGene: Cel.16995

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Transmembrane Protein Questionnaire with Gifts

Email: [email protected]
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Service

Phage Display Service

Antibody Service

Protein Service

Gene Synthesis Service

Oligo Synthesis Service

Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Call us

301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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