age-1 Antibody

1. synaptic PI3K Age-1 is crucial for the behavioral switch caused by learning. PMID: 25035490
2. ASM-3 acid sphingomyelinase functions as a positive regulator of the DAF-2/AGE-1 signaling pathway and serves as a novel anti-aging target PMID: 23049887
3. The number of nonredundant gene ontology categories significantly distinguishing age-1 alleles of exceptional longevity increased from sevenfold to greater than ninefold. PMID: 22021389
4. conclude that extreme age-1 deficiency invokes multiple transcriptional changes. PMID: 19764929
5. During neuronal development, mig-10 and the C. elegans Ena/VASP homolog unc-34 cooperate to guide axons toward UNC-6 (netrin) and away from SLT-1 (Slit). PMID: 16618541
6. Results showed that age-1 mutant phenotypes identified activating mutations in two known pathway components, providing insights into their regulation. PMID: 17020605
7. C. elegans strains bearing homozygous nonsense mutations in the age-1 gene after prolonged developmental times at 15-20 degrees C, mature into extremely long-lived adults with near-normal feeding rates and motility. PMID: 17996009
8. In the age-1 allele, which activates an insulin/insulin-like growth factor-1 (Ins/IGF-1) signaling pathway, the superoxide dismutase (SOD) and catalase activities increased during normal aging. PMID: 18285659
9. Reuslts identify four genes to be required for the quercetin derived lifespan extension in C. elegans, namely age-1, daf-2, unc-43 and sek-1. PMID: 19043800
10. Our findings demonstrate a drug-specific interaction between clozapine and the PI3K/insulin-signaling pathway in C. elegans. PMID: 19322168
11. Suppression of age-1 contributes to exceptional survival. PMID: 19360094
12. Studies show that strong mutations to the encoding AGE-1/PI3KCS achieve unprecedented longevity by orchestrating the modulation (predominantly silencing) of multiple signaling pathways. PMID: 19465083

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KEGG: cel:CELE_B0334.8

STRING: 6239.B0334.8

UniGene: Cel.18292