adgrg6 Antibody

Datasheet

Code	CSB-PA009747XA01DIL
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Target Background

Product Details

Full Product Name

Rabbit anti-Danio rerio (Zebrafish) (Brachydanio rerio) adgrg6 Polyclonal antibody

Uniprot No.

C6KFA3

Target Names

adgrg6

Alternative Names

adgrg6 antibody; gpr126Adhesion G-protein coupled receptor G6 antibody; G-protein coupled receptor 126) [Cleaved into: ADGRG6 N-terminal fragment antibody; ADGRG6-NTF); ADGRG6 C-terminal fragment antibody; ADGRG6-CTF)] antibody

Raised in

Rabbit

Species Reactivity

Danio rerio (Zebrafish) (Brachydanio rerio)

Immunogen

Recombinant Danio rerio (Zebrafish) (Brachydanio rerio) adgrg6 protein

Immunogen Species

Danio rerio (Zebrafish) (Brachydanio rerio)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB (ensure identification of antigen)

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Value-added Deliverables

① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);

Quality Guarantee

① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;

Lead Time

Made-to-order (14-16 weeks)

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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Target Background

Function

G-protein coupled receptor which is activated by type IV collagen, a major constituent of the basement membrane. Couples to G(i)-proteins as well as G(s)-proteins. Essential for normal differentiation of promyelinating Schwann cells and for normal myelination of axons. Plays also a role in inner ear development.; Plays an important role in heart development. Necessary and sufficient for axon sorting by Schwann cells independently of the ADGRG6-CTF.

Gene References into Functions

A new zebrafish mutation that truncates Gpr126 disrupted development of peripheral nerves and the inner ear. PMID: 25118328
GPR126 modulates both physiological and pathological angiogenesis through VEGF signaling PMID: 25217645
a model in which the NTF of Gpr126, in contrast to the C-terminal fragment, plays an important role in heart development. PMID: 24082093
Gpr126 acts through a cAMP-mediated pathway to control the outgrowth and adhesion of canal projections in the zebrafish ear via the regulation of extracellular matrix gene expression. PMID: 24067352
gpr126 mutant Schwann cells elaborate mature myelin sheaths and maintain krox20 expression for months, provided that the early signaling defect is bypassed by transient elevation of cAMP. PMID: 23804499
study found that Gpr126 is required autonomously in Schwann cells for myelination; propose that Gpr126 drives the differentiation of promyelinating Schwann cells by elevating cAMP levels, thereby triggering Oct6 expression and myelination PMID: 19745155

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Subcellular Location

Cell membrane; Multi-pass membrane protein.

Protein Families

G-protein coupled receptor 2 family, Adhesion G-protein coupled receptor (ADGR) subfamily

Tissue Specificity

Expressed in Schwann cells of the posterior lateral line nerve and in brain.

Database Links

KEGG: dre:561970

STRING: 7955.ENSDARP00000109070

UniGene: Dr.76404

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Service

Phage Display Service

Antibody Service

Protein Service

Gene Synthesis Service

Oligo Synthesis Service

Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Related pathways

G protein coupled receptor signaling pathway

Call us

301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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adgrg6 Antibody

Product Details

Related Products

Customer Reviews and Q&A

Target Background