AHP1 Antibody

Code CSB-PA330808XA01SVG
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Product Details

Full Product Name
Rabbit anti-Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) AHP1 Polyclonal antibody
Uniprot No.
Target Names
AHP1
Alternative Names
AHP1 antibody; YLR109W antibody; L2916 antibody; L9354.5Peroxiredoxin AHP1 antibody; Prx antibody; EC 1.11.1.15 antibody; Alkyl hydroperoxide reductase antibody; AHPC1 antibody; Cytoplasmic thiol peroxidase 3 antibody; cTPx 3 antibody; Thiol-specific antioxidant II antibody; TSA II antibody; Thioredoxin peroxidase type II antibody; TPx type II antibody
Raised in
Rabbit
Species Reactivity
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Immunogen
Recombinant Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) AHP1 protein
Immunogen Species
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. Preferentially eliminates organic peroxides rather than hydrogen peroxide. Relays alkyl hydroperoxides as a signal to the transcription factor CAD1/YAP2 by inducing the formation of intramolecular disulfide bonds in CAD1, which causes its nuclear accumulation and activation. Involved in cellular Mn(2+) homeostasis.
Gene References into Functions
  1. The results point to the stress-related proteins Ahp1, Yhb1 and Oye2, as well as Gln1 and Kes1 as putative candidates for being evaluated as biomarkers for diagnostic assays of S. cerevisiae infections. PMID: 25173100
  2. Its overexpression results in a reduced ROS level and fails to reverse saccharomyces cerevisiae gorowth defect in the stationary phase. PMID: 24418709
  3. The structure of the Ahp1-Trx2 complex showed for the first time how the electron transfers from thioredoxin to a peroxidase with a thioredoxin-like fold. PMID: 22474296
Subcellular Location
Cytoplasm.
Protein Families
Peroxiredoxin family, Prx5 subfamily
Database Links

KEGG: sce:YLR109W

STRING: 4932.YLR109W

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