Product Details

Full Product Name

Rabbit anti-Arabidopsis thaliana (Mouse-ear cress) AKR2A Polyclonal antibody

Uniprot No.

Q9SAR5

Target Names

AKR2A

Alternative Names

AKR2A antibody; AFT antibody; AKR2 antibody; At4g35450 antibody; F15J1.20Ankyrin repeat domain-containing protein 2A antibody; AtAKR2 antibody

Raised in

Rabbit

Species Reactivity

Arabidopsis thaliana

Immunogen

Recombinant Arabidopsis thaliana AKR2A protein

Immunogen Species

Arabidopsis thaliana (Mouse-ear cress)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB (ensure identification of antigen)

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Value-added Deliverables

① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);

Quality Guarantee

① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;

Lead Time

Made-to-order (14-16 weeks)

Target Background

Function

Exhibits chaperone activity toward chloroplast outer envelope membrane, mitochondrion outer membrane, endoplasmic reticulum membrane and peroxisomal proteins, by recruiting specific proteins containing a single transmembrane associated with an AKR2A-binding sequence (ABS) and subsequently binding glycolipids (e.g. monogalactosyldiacylglycerol (MGDG) and phosphatidylglycerol (PG)) present in the membrane of the target organelle. Seems to be involved in the regulation of hydrogen peroxide levels during biotic and abiotic stresses by optimizing the ascorbate peroxidase 3 (APX3) hydrogen peroxide-degrading activity. This regulation might be monitored by GRF6. Cytosolic targeting factor for chloroplast outer membrane (COM) proteins that mediates sorting and targeting of nascent chloroplast outer envelope membrane (OEM) proteins to the chloroplast. Facilitates the targeting of OEP7 to chloroplasts. Facilitates the targeting of APX3 to peroxisomes. Involved in cellular metabolism (e.g. peroxisome activity) and required for plant growth and development.

Gene References into Functions

AKR2A-mediated targeting of chloroplast outer membrane proteins is coupled to their translation, which in turn is crucial for biogenesis of the entire chloroplast proteome. PMID: 25880450
the AKR2 ankyrin repeat domain drives chloroplast targeting through coincident binding of two chloroplast lipids PMID: 25203210
The role of AKR2A in the regulation of at least 500 genes in the Arabidopsis genome is discussed. PMID: 21057222
AKR2A is a molecular chaperone that binds specifically to APX3 and to five other single-membrane spanning proteins. PMID: 20215589
AKR2A functions as a cytosolic mediator for sorting and targeting of nascent chloroplast OEM proteins to the chloroplast. PMID: 18193034

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Subcellular Location

Cytoplasm. Nucleus. Plastid, chloroplast outer membrane; Peripheral membrane protein; Cytoplasmic side.

Tissue Specificity

Ubiquitously expressed at basal level.

Database Links

KEGG: ath:AT4G35450

STRING: 3702.AT4G35450.5

UniGene: At.24072

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AKR2A Antibody

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