Aldh1a2 Antibody

Code CSB-PA714348XA01RA
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Product Details

Full Product Name
Rabbit anti-Rattus norvegicus (Rat) Aldh1a2 Polyclonal antibody
Uniprot No.
Target Names
Alternative Names
Aldh1a2 antibody; Raldh2 antibody; Retinal dehydrogenase 2 antibody; RALDH 2 antibody; RalDH2 antibody; EC 1.2.1.36 antibody; Aldehyde dehydrogenase family 1 member A2 antibody; Retinaldehyde-specific dehydrogenase type 2 antibody; RALDH(II) antibody
Raised in
Rabbit
Species Reactivity
Rattus norvegicus (Rat)
Immunogen
Recombinant Rattus norvegicus (Rat) Aldh1a2 protein
Immunogen Species
Rattus norvegicus (Rat)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)
Usage
For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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Target Background

Function
Converts retinaldehyde to retinoic acid. Recognizes as substrates free retinal and cellular retinol-binding protein-bound retinal. Can metabolize octanal and decanal, but has only very low activity with benzaldehyde, acetaldehyde and propanal. Displays complete lack of activity with citral.
Gene References into Functions
  1. This study is the first to show that RALDH2 and RALDH3, but not RALDH1, are expressed in the embryonic anterior pituitary gland of the rat. PMID: 17180597
  2. inhibited by compounds that induce congenital diaphragmatic hernias (CDH); data provide an important component of mounting evidence suggesting that the retinoid system warrants consideration in future studies of the etiology of CDH. PMID: 12547725
  3. Results suggest that postnatal expressions of hepatocyte-specific genes might be up-regulated by retinoid receptors, which may be related with the alterations of RALDH expression during postnatal development in the liver. PMID: 14729401
  4. eRolDH and RalDH II and their mRNAs were increased in uteri of rats during estrus. RalDH II was observed in the stromal compartment, particularly in cells close to the uterine lumenal epithelium. PMID: 15205379
Subcellular Location
Cytoplasm.
Protein Families
Aldehyde dehydrogenase family
Tissue Specificity
Found in testis and less abundantly in lung, brain, heart, liver and kidney.
Database Links
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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
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Address
7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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