anc-1 Antibody

Code CSB-PA865059XA01CXY
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Product Details

Full Product Name
Rabbit anti-Caenorhabditis elegans anc-1 Polyclonal antibody
Uniprot No.
Target Names
anc-1
Alternative Names
anc-1 antibody; ZK973.6Nuclear anchorage protein 1 antibody; Anchorage 1 protein antibody; Nesprin homolog antibody
Raised in
Rabbit
Species Reactivity
Caenorhabditis elegans
Immunogen
Recombinant Caenorhabditis elegans anc-1 protein
Immunogen Species
Caenorhabditis elegans
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
Plays a central role in nuclear and mitochondrial anchoring. Probably connects nuclei to the cytoskeleton by interacting with unc-84 at the nuclear envelope and with F-actin in the cytoplasm, creating a bridge across the nuclear envelope between the cytoskeleton and the nucleus. Has a role in positioning of the cell body of the PVQ lumbar interneuron.
Gene References into Functions
  1. Our study highlights an emerging, broad role for ANC-1 in neuronal development, and unveils a new and unexpected mechanism by which RPM-1 functions. PMID: 25010424
Subcellular Location
Nucleus outer membrane; Single-pass type IV membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton.
Protein Families
Nesprin family
Tissue Specificity
Ubiquitously expressed in all postembryonic cells.
Database Links

STRING: 6239.ZK973.6

UniGene: Cel.22568

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