Product Details

Full Product Name

Rabbit anti-Caenorhabditis elegans prmt-1 Polyclonal antibody

Uniprot No.

Q9U2X0

Target Names

prmt-1

Alternative Names

prmt-1 antibody; epg-11 antibody; Y113G7B.17Protein arginine N-methyltransferase 1 antibody; EC 2.1.1.319 antibody

Raised in

Rabbit

Species Reactivity

Caenorhabditis elegans

Immunogen

Recombinant Caenorhabditis elegans prmt-1 protein

Immunogen Species

Caenorhabditis elegans

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB (ensure identification of antigen)

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Value-added Deliverables

① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);

Quality Guarantee

① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;

Lead Time

Made-to-order (14-16 weeks)

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Target Background

Function

Arginine methyltransferase that methylates (mono and asymmetric dimethylation) the guanidino nitrogens of arginyl residues present in target proteins. Catalyzes the formation of monomethylarginine and asymmetric dimethylarginine on histones H2A and H4, a specific tag for epigenetic transcriptional activation. Catalyzes asymmetric arginine dimethylation of mitochondrial proteins necessary for mitochondrial oxidative phosphorylation activity and thus aerobic respiration and ATP synthesis, and the mitochondrial stress response. Methylates arginine residues in P-granule components pgl-1 and pgl-3 to promote P-granule degradation by autophagy in somatic cells to ensure exclusive localization of the P-granules in germ cells. Modulates the interaction of P-granule proteins epg-2 and sepa-1. Methylates arginine residues in daf-16, which blocks ftt-2 binding to daf-16, prevents akt-mediated phosphorylation and allows for daf-16 to translocate to the nucleus. In turn, association with daf-16 therefore allows for the transcriptional activation of daf-16 and regulation of longevity-related genes. Maintains lifespan by modulating daf-16 activity downstream of the daf-2 signaling pathway. Plays a role in heat and oxidative stress resistance. Role in stress resistance and also fat storage may be in association with the daf-2 signaling pathway. Required for normal feeding behavior.

Gene References into Functions

It show the morphological and functional phenotypes of single or double null alleles of prmt-1 in Caenorhabditis elegans. The prmt-1;prmt-5 double mutants are viable, and exhibit short body length and small brood size compared to N2 and each of the single mutants. PMID: 28158808

Subcellular Location

Cytoplasm. Nucleus.

Protein Families

Class I-like SAM-binding methyltransferase superfamily, Protein arginine N-methyltransferase family

Tissue Specificity

Widely expressed in pharyngeal, body wall muscle, intestinal and vulval cells.

Database Links

KEGG: cel:CELE_Y113G7B.17

STRING: 6239.Y113G7B.17.1

UniGene: Cel.22752

Message

Product >> Product Name：
Product >> Code：
Name： *
Email： *
Company/Organization：
Phone：
Since emails may get flagged by spam filters occasionally, we recommend leaving your phone number as a precaution. Your information is safe with us.
Question/Comment： *
Your Region： *
I'd like to receive email newsletters from Cusabio

Yes

No
How do you know CUSABIO?

Email

Distributor

Search engine

Advertisement

Others
CAPTCHA verification：

Code	CSB-PA183069XA01CXY
Size	Enquire
Have Questions?	Leave a Message or Start an on-line Chat

prmt-1 Antibody

Product Details

Customer Reviews and Q&A

Target Background