Aox1 Antibody

Code CSB-PA001858XA01MO
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Product Details

Full Product Name Rabbit anti-Mus musculus (Mouse) Aox1 Polyclonal antibody
Uniprot No. O54754
Target Names Aox1
Alternative Names Aox1 antibody; Ao antibody; Ro antibody; Aldehyde oxidase 1 antibody; EC 1.2.3.1 antibody; Azaheterocycle hydroxylase 1 antibody; EC 1.17.3.- antibody; Retinal oxidase antibody
Raised in Rabbit
Species Reactivity Mus musculus (Mouse)
Immunogen Recombinant Mus musculus (Mouse) Aox1 protein
Immunogen Species Mus musculus (Mouse)
Conjugate Non-conjugated
Clonality Polyclonal
Isotype IgG
Purification Method Protein A/G
Concentration It differs from different batches. Please contact us to confirm it.
Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form Liquid
Tested Applications ELISA, WB (ensure identification of antigen)
Protocols ELISA Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables ① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee ① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time Made-to-order (14-16 weeks)

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Target Background

Function
(From Uniprot)
Oxidase with broad substrate specificity, oxidizing aromatic azaheterocycles, such as N1-methylnicotinamide, N-methylphthalazinium and phthalazine, as well as aldehydes, such as benzaldehyde, retinal, pyridoxal, and vanillin. Plays a role in the metabolism of xenobiotics and drugs containing aromatic azaheterocyclic substituents. Participates in the bioactivation of prodrugs such as famciclovir, catalyzing the oxidation step from 6-deoxypenciclovir to penciclovir, which is a potent antiviral agent. Also plays a role in the reductive metabolism of the xenobiotic imidacloprid (IMI) via its nitroreduction to nitrosoguanidine (IMI-NNO) and aminoguanidine (IMI-NNH(2)). Is probably involved in the regulation of reactive oxygen species homeostasis. May be a prominent source of superoxide generation via the one-electron reduction of molecular oxygen. Also may catalyze nitric oxide (NO) production via the reduction of nitrite to NO with NADH or aldehyde as electron donor. May play a role in adipogenesis. Cannot use xanthine and hypoxanthine as substrate.
Gene References into Functions
  1. Although mAOX2 and mAOX3 are very similar to each other, we propose the following pairs of overlapping substrate specificities: mAOX2/mAOX4 and mAOX3/mAXO1. PMID: 25287365
  2. findings suggest that AOX1 acts as a contributor to the process of myogenesis by influencing the level of H2O2 PMID: 24996175
  3. These data indicate that AOX1 is essential for adipogenesis and may link energy and drug metabolism. PMID: 18671973
  4. only Glu1265 is essential for catalytic activity by initiating the base-catalyzed mechanism of substrate oxidation PMID: 19401776
Subcellular Location Cytoplasm.
Protein Families Xanthine dehydrogenase family
Tissue Specificity Highest expression in esophagus. Moderately low expression in lung, liver, heart, Harderian gland, olfactory mucosa, skin and testis. In brain, expression is very high in choroid plexus, high in hind brain and low in hippocampus and cerebellum. In spinal
Database Links

KEGG: mmu:11761

STRING: 10090.ENSMUSP00000001027

UniGene: Mm.26787

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