ap Antibody

Code CSB-PA329930XA01DLU
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Product Details

Full Product Name
Rabbit anti-Drosophila melanogaster (Fruit fly) ap Polyclonal antibody
Uniprot No.
Target Names
ap
Alternative Names
ap antibody; CG8376Protein apterous antibody
Raised in
Rabbit
Species Reactivity
Drosophila melanogaster (Fruit fly)
Immunogen
Recombinant Drosophila melanogaster (Fruit fly) ap protein
Immunogen Species
Drosophila melanogaster (Fruit fly)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
Required for the normal development of the wing and halter imaginal disks.
Gene References into Functions
  1. neurons expressing the transcription factor apterous, affect the modulation of female walking speed during courtship. PMID: 28401905
  2. These results raise the possibility that the daily oscillation of Ap expression in l-LNvs may contribute to the buffering of light-driven arousal in wild-type flies. PMID: 27853240
  3. Ap role in the neuronal cell fate specification PMID: 27148744
  4. Nplp1 neuropeptide neurons in the developing Drosophila nerve cord belong to two sub-classes; Tv1 and dAp neurons, generated by two distinct progenitors. Nplp1 neurons are specified by spatial cues PMID: 28414802
  5. our results indicate that ap is regulated in time and space by a three-step mechanism that generates a lineage compartment by integrating input from separatecis-regulatory modules for the initiation, refinement and maintenance of its expression PMID: 26468882
  6. in brain development, Ap is required for correct axon guidance and fasciculation of interneurons, and Ap-expressing cells may also be involved in the brain neuroendocrine system. PMID: 11862460
  7. Data show that normal cell proliferation is necessary for apterous expression at the level of the dorso-ventral boundary, which is mediated by vestigial, interacting in a dose-dependent way with apterous. PMID: 12485165
  8. necessary for expression of the Leucokinin neuropeptide in a pair of brain neurons located in the lateral horn region of the protocerebrum PMID: 12541314
  9. in the absence of vg, the IFM developmental program switches into the DFM developmental program.DFM development requires key regulatory genes such as cut (ct) and apterous (ap), whereas IFM development requires vestigial (vg). PMID: 12921740
  10. Apterous (Ap, a selector protein), and the Notch and Wingless (Wg) signaling pathways, can sequentially control wing development through direct regulation of Ser expression in instar stages PMID: 14701680
  11. Osa, a member of the Brahma chromatin-remodeling complex, as a positive modulator of Apterous activity in the Drosophila wing PMID: 15147766
  12. A new instance of transvection at the Drosophila apterous (ap) locus, is reported. PMID: 18202363
  13. The AP and NAT activities in ap56f females were significantly lower than in Canton S females in the norm PMID: 18672805

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Subcellular Location
Nucleus.
Tissue Specificity
Expressed in PNS and CNS.
Database Links

KEGG: dme:Dmel_CG8376

STRING: 7227.FBpp0085394

UniGene: Dm.4746

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