arm Antibody

1. Study showed that the highly evolutionary conserved Y654 beta-cat-D665-E-cad major interaction site of the adherens junctions complex acts as primary mechanosensor. The site activates the beta-cat pathway through its mechanical opening in vivo that enables phosphorylation by Src42A kinase. PMID: 30024850
2. Manipulating Axin or APC2 levels had no effect on beta-catenin destruction complex activity when Wnt signals were absent, but, surprisingly, had opposite effects on the destruction complex when Wnt signals were present. Elevating Axin made the complex more resistant to inactivation, while elevating APC2 levels enhanced inactivation. PMID: 29641560
3. here we examine the interactions between Msk and the Wg pathway in regulation of the AMP pool size. We find that a myoblast-specific reduction of Msk results in the absence of Vg expression and a complete loss of the Wg pathway readout beta-catenin/Armadillo (Arm). Moreover, msk RNA interference knockdown abolishes expression of the Wg target Ladybird (Lbe) in leg disc myoblasts. PMID: 28249984
4. An absolute requirement for Armadillo for activation and repression of Wingless protein target genes PMID: 28369070
5. The data suggests that arm-Gal4 has detrimental effects on Drosophila development and lifespan that are directly dependent upon parental inheritance PMID: 26505429
6. dissociation of tyrosine-phosphorylated Arm from DE-cadherin allows dynamic actin to reorganize, leading to ring canal expansion and cell shape changes during the course of oogenesis PMID: 25803041
7. Armless may promote Wg signaling by rescuing Armadillo from proteolytic degradation. PMID: 25369031
8. Reduced Klp64D function is suppressed by activated Arm. PMID: 25063455
9. Arm activity strongly suppresses supernumerary neuroblasts induced by overexpression of klu. PMID: 24257623
10. Results implicate a previously unrecognized function for miR-310/13 in dampening the activity of Arm in early somatic and germline progenitor cells, whereby inappropriate/sustained activation of Arm-mediated signaling or cell adhesion may impact normal differentiation in the Drosophila male gonad. PMID: 23821034
11. Arm is found at the plasma membrane of all epithelial cells, as part of the cadherincatenin complex PMID: 22359584
12. Binding of Arm to DE-cadherin is weaker in polarizing cells than in polarized cells. PMID: 22159415
13. Data show that Hipk dually regulates both Wingless and Hedgehog signaling by impeding the function of the E3 ubiquitin ligase complex, thereby inhibiting Armadillo ubiquitination and subsequent degradation. PMID: 21628596
14. In the current model of Wnt signalling, a complex assembled around Axin and Apc allows GSK3 (Shaggy) to phosphorylate Armadillo and target it for degradation. PMID: 21389052
15. the Hippo pathway restricts Wnt/beta-Catenin signaling by promoting an interaction between TAZ and DVL in the cytoplasm PMID: 20412773
16. Data show that in arm mutants, even a modest reduction in the basolateral component lgl leads to a full apical domain expansion or lgl phenotype. PMID: 19737741
17. proper polarity in the late embryo involves the asymmetric distribution and phosphorylation of Armadillo at the membrane, and interference with this Arm phosphorylation leads to polarity defects PMID: 17183721
18. Data show that wingless (wg) represses transcription of the dpp gene in the ventral leg disc, and that this repression requires a tri-partite complex of the WG mediators armadillo and dTCF, and the co-repressor Brinker. PMID: 17206277
19. Control of beta-catenin phosphorylation/degradation by a dual-kinase mechanism PMID: 11955436
20. MyoVI is required for border cell migration where it stabilizes E-cadherin and Arm. PMID: 12134162
21. The Drosophila clock protein Timeless is a member of the Arm/HEAT family. PMID: 12372263
22. we find a strong correlation between progression through mitosis and a reduction in Armadillo levels.We conclude that this phenomenon may reduce the efficacy of Wingless signalling and/or intercellular adhesion during cell division. PMID: 12559488
23. elucidation of signaling in nucleus PMID: 12646868
24. Results show that a vital regulatory step in Wingless signaling is Zeste white 3-mediated Armadillo phosphorylation. PMID: 14966281
25. Tws is required for the stabilization of Armadillo/beta-catenin in response to Wg/Wnt signaling. PMID: 14973271
26. armadillo/beta-catenin has a nuclear function PMID: 15024404
27. Pygo and Lgs function in targeting Armadillo/beta-catenin to the nucleus, thus ensuring its availability to TCF during Wnt signalling. PMID: 15208637
28. Armadillo/beta-catenin-dependent Wnt signalling is required for the polarisation of epidermal cells during dorsal closure in Drosophila PMID: 15226252
29. Data show that Drosophila Hyrax and its human ortholog, Parafibromin, are required for nuclear transduction of the Wnt/Wg signal and bind directly to the C-terminal region of beta-catenin/Armadillo. PMID: 16630820
30. The activity of armadillo is regulated by Notch synergizing with axin in Drosophila. PMID: 16881048
31. binding per se of beta-catenin by adenomatous polyposis coli does not require phosphorylation by GSK-3beta PMID: 17968317
32. Wg, beta-catenin, and decapentaplegic regulate the division of embryonic PGCs in a stage-specific manner PMID: 18291628
33. Data show that Drosophila Naked cuticle (Nkd) engages the nuclear import adaptor Importin-alpha3 to antagonize Wnt/beta-catenin signaling. PMID: 18423435
34. Mbt activation destabilizes Drosophila Armadillo with DE-cadherin resulting in a decrease in DE-cadherin-mediated adhesiActivation of Mbt leads to destabilization of Drosophila Armadillo with DE-cadherin resulting in decreasing cadherin-mediated adhesion. PMID: 18636970
35. In vivo evidence for a complex non-linear elationship between Armadillo levels, subcellular distribution and Wingless signalling. PMID: 18682750
36. Bone morphogenetic protein pathway components can repress Wg target gene expression by influencing the binding of Arm and dTcf. PMID: 19065265
37. Using both in vitro and in vivo assays, Hipk was found to promote the stabilization of Arm. PMID: 19088090
38. Arm is a major regulator of cadherin-mediated adhesion and is cleaved by caspases in embryo extracts and study provides evidence that the caspase-3 homolog drICE cleaves Arm in vitro and in vivo. PMID: 19232093
39. Data suggest that DE-cadherin/armadillo form part of the mechanism that control branching and trajectory of axon tracts in the larval brain. PMID: 19520071
40. Data have identified PR55 alpha as the regulatory subunit of PP2A that controls beta-catenin phosphorylation and degradation. PR55 alpha, but not the catalytic subunit, PP2Ac, directly interacts with beta-catenin. PMID: 19556239
41. Notch can promote the degradation of activated forms of Armadillo and may buffer cells against fluctuations in Wnt signalling activity. PMID: 19668359
42. differential requirements of contact residues in Axin for interactions with GSK3beta or beta-catenin. PMID: 19850033

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KEGG: dme:Dmel_CG11579

STRING: 7227.FBpp0089035

UniGene: Dm.4782