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manf-1 Antibody

Datasheet
Code CSB-PA878800XA01CXY
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Product Details

Full Product Name
Rabbit anti-Caenorhabditis elegans manf-1 Polyclonal antibody
Uniprot No.
Q9N3B0
Target Names
manf-1
Alternative Names
manf-1 antibody; Y54G2A.23 antibody; Mesencephalic astrocyte-derived neurotrophic factor homolog antibody; ARMET-like protein antibody; MANF/CDNF-like protein antibody
Raised in
Rabbit
Species Reactivity
Caenorhabditis elegans
Immunogen
Recombinant Caenorhabditis elegans manf-1 protein
Immunogen Species
Caenorhabditis elegans
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
ELISA Protocol
Troubleshooting and FAQs
Antibody FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

Related Products

manf-1 Proteins

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Target Background

Function
Inhibits endoplasmic reticulum (ER) stress response. Retained in the ER under normal conditions and is up-regulated and secreted by the ER in response to ER stress and hypoxia. Following secretion by the ER, directly binds to 3-O-sulfogalactosylceramide, a lipid sulfatide in the outer cell membrane of target cells. Sulfatide binding promotes its cellular uptake by endocytosis, and is required for its role in alleviating ER stress under ER stress conditions. Has a neuroprotective role, ensuring survival of dopaminergic neurons during normal growth.
Gene References into Functions
  1. Sulfatide binding promotes cellular MANF uptake and cytoprotection from hypoxia-induced cell death. PMID: 29497057
Subcellular Location
Secreted. Endoplasmic reticulum lumen.
Protein Families
ARMET family
Tissue Specificity
Expressed in the intestine, spermatheca and nervous system. Expressed in the hypoderm. Expressed in structures of the excretory system. Not expressed in the male gonad.
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