tgo Antibody

Code CSB-PA522690XA01DLU
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Product Details

Full Product Name
Rabbit anti-Drosophila melanogaster (Fruit fly) tgo Polyclonal antibody
Uniprot No.
Target Names
tgo
Alternative Names
tgo antibody; ARNT antibody; HIF-1-beta antibody; CG11987Aryl hydrocarbon receptor nuclear translocator homolog antibody; dARNT antibody; Hypoxia-inducible factor 1-beta antibody; Protein tango antibody
Raised in
Rabbit
Species Reactivity
Drosophila melanogaster (Fruit fly)
Immunogen
Recombinant Drosophila melanogaster (Fruit fly) tgo protein
Immunogen Species
Drosophila melanogaster (Fruit fly)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
Heterodimers of tgo/trh are involved in the control of breathless expression. Plays a role in the cellular or tissue response to oxygen deprivation.
Gene References into Functions
  1. Maintenance of ER/Golgi architecture and bulky cargo transport are the primary functions for Tango1. PMID: 29138315
  2. the Tango-Trace strategy we used may be applied more generally to identify neural circuits in the fly brain PMID: 25043419
  3. These results together identify TGO's transactivation domain and establish its importance for proper target gene regulation and cellular specification. PMID: 15818484
  4. HIF-1 control of heat shock factor transcriptional levels is a regulatory mechanism for sensitizing heat shock pathway activity in order to maximize production of protective heat shock proteins PMID: 17040902
  5. Dysfusion dimerizes with the Tango bHLH-PAS protein, and together they act as a DNA binding transcriptional activator PMID: 17652079

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Subcellular Location
Nucleus.
Tissue Specificity
At stage 11, expression is detected in tracheal pits. At later stages, strong expression is also detected in the CNS.
Database Links

KEGG: dme:Dmel_CG11987

STRING: 7227.FBpp0081483

UniGene: Dm.3376

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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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