ARP Antibody

Datasheet

Code	CSB-PA332781XA01DOA
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Product Details

Full Product Name

Rabbit anti-Arabidopsis thaliana (Mouse-ear cress) ARP Polyclonal antibody

Uniprot No.

P45951

Target Names

ARP

Alternative Names

ARP antibody; REF antibody; At2g41460 antibody; T26J13.5DNA-(apurinic or apyrimidinic site) lyase antibody; chloroplastic antibody; EC 4.2.99.18 antibody; Apurinic endonuclease-redox protein antibody

Raised in

Rabbit

Species Reactivity

Arabidopsis thaliana

Immunogen

Recombinant Arabidopsis thaliana ARP protein

Immunogen Species

Arabidopsis thaliana (Mouse-ear cress)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB (ensure identification of antigen)

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Value-added Deliverables

① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);

Quality Guarantee

① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;

Lead Time

Made-to-order (14-16 weeks)

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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Target Background

Function

Repairs oxidative DNA damages, seems also to act as a redox factor. Is multifunctional and may be involved both in DNA repair and in the regulation of transcription. Exhibits apurinic/apyrimidinic (AP) endonuclease activity. Catalyzes the conversion of 3'-phosphor-alpha,beta-unsaturated aldehyde (3'-PUA) to 3'-OH. May be involved in base excision repair in chloroplasts. According to a report, has a significant in vitro 3'-phosphatase activity. According to another report, has no in vitro 3'-phosphatase activity. Has a strong non-specific affinity to DNA.

Gene References into Functions

The major Arabidopsis thaliana apurinic/apyrimidinic endonuclease, ARP, is involved in the plant nucleotide incision repair pathway. PMID: 27836324
ARP is the major AP endonuclease activity in Arabidopsis cells, and is required for base excision repair of both uracil and synthetic AP sites in vitro. PMID: 21781197
plants with knock-out mutations in any one of Ape1L, Ape2, or Arp show no apparent differences from wild type in growth rate, growth habit, and fertility PMID: 19172180

Subcellular Location

Plastid, chloroplast stroma, chloroplast nucleoid.

Protein Families

DNA repair enzymes AP/ExoA family

Tissue Specificity

Expressed in the siliques, flowers, and stems. A high level expression is seen in the leaves. Expressed in both vegetative and reproductive organs.

Database Links

KEGG: ath:AT2G41460

STRING: 3702.AT2G41460.1

UniGene: At.25567

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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ARP Antibody

Product Details

Related Products

Customer Reviews and Q&A

Target Background