ARP2 Antibody

1. ARP2 role in the actin filament nucleation. PMID: 27417392
2. WASP displaces the autoinhibitory Arp3 C-terminal tail from a hydrophobic groove at Arp3's barbed end to destabilize the inactive state, providing a mechanism by which WASP stimulates the short-pitch conformation and activates the Arp2/3 complex. PMID: 27325766
3. Studies indicate that the WASP homologue Las17 is able to nucleate actin independently of Arp2/3 through the function of G-actin-binding activities in its polyproline region. PMID: 27911716
4. data does not support the simple hypothesis that the primary role for Arp2/3 regulators is to recruit and activate Arp2/3; rather data suggests that these regulators may be playing more subtle roles in establishing functional networks in vivo PMID: 23200048
5. study showed that subunit ARPC1/Arc40 of the yeast actin-related protein Arp2/3 complex is indeed a stable component of the complex and contains an important contact site for the VCA domain of Wiskott-Aldrich syndrome protein family activators PMID: 15485833
6. WASp stabilizes p35-dependent closure of the complex, holding Arp2 and Arp3 closer together to nucleate an actin filament. PMID: 15592479
7. Binding of Arp2 with Arp3 nucleotide was found to be important for actin nucleating activity. PMID: 15657399
8. investigated the ability of the yeast Arp2/3 complex (yArp2/3) to facilitate yeast actin polymerization in the presence and absence of the Arp2/3-activating factor Las17p WA PMID: 15857833
9. Arp2 ATP-hydrolysis mutants exhibit defects in endocytic internalization and actin-network disassembly. PMID: 16862144
10. These findings reveal that Arp2p also mediates what appears to be an auto-regulatory mechanism possibly adapted for efficient coordination of actin assembly and disassembly during endocytosis. PMID: 17978096
11. An actin-related protein, Arp2, briefly colocalizes with Atg9 and directly regulates the dynamics of Atg9 movement. PMID: 18287533
12. analysis of the key surfaces on p35/ARPC2 required for Arp2/3 complex-mediated actin assembly and cellular function PMID: 18381280

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KEGG: sce:YDL029W

STRING: 4932.YDL029W