Arr2 Antibody

1. Rapid calcium/calmodulin-dependent release of arrestin (Arr)2 from NINAC upon Ca2+ influx accounts for the acceleration of translocation by phototransduction. PMID: 22764229
2. This study indicated that Arr2 translocation in Drosophila photoreceptors is driven by diffusion, but profoundly accelerated by phototransduction and Ca2+ influx. PMID: 20869596
3. We developed a steady-state stochastic model to interpret the dependence of the PDA on effective light intensity and arrestin content and to help deduce the arrestin to rhodopsin ratio from the sensitivity and PDA data. PMID: 19924417
4. a constitutively active arrestin mutant can both induce agonist-independent internalization and stabilize the agonist-high affinity state of an arrestin-insensitive G protein coupled receptor. PMID: 12695524
5. news: beta-arrestin is now identified as a regulator of ubiquination and degradation of the Notch receptor PMID: 16319967
6. data suggest a novel model of arrestin-2 regulation mediated by inositol hexakisphosphate PMID: 16439357
7. Data show that the endocytic adapter protein AP-2 is essential for rhodopsin endocytosis through an arrestin2-AP-2beta interaction. PMID: 16835270
8. CaMKII is involved in the negative regulation of the visual response affecting light adaptation, possibly by catalyzing phosphorylation of Arr2 PMID: 19254957

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KEGG: dme:Dmel_CG5962

STRING: 7227.FBpp0076326

UniGene: Dm.7211