ASF1 Antibody

1. he model provides a molecular basis for the involvement of both Vps75 and Asf1 in Rtt109 catalysed histone H3 K9 acetylation. In the absence of Asf1 this model can be used to generate a complex consisting of a reconfigured Vps75 tetramer bound to a H3-H4 tetramer. PMID: 27036862
2. dissociation of histone H3 from Asf1 is required for efficient recovery and that Asf1 is required for complete dephosphorylation of Rad53 when the upstream DNA damage checkpoint signaling is turned off PMID: 27222517
3. These results along with high association of Asf1 with heterochromatic centromeres and telomeres ascribe novel roles to Asf1 in condensin loading and chromatin dynamics. PMID: 25264624
4. acetylation of histone H4 K12 by Rtt109-Vps75, whereas Rtt109-Asf1 showed no detectable activity toward H4. PMID: 23036725
5. A region (amino acids [aa] 188 to 231) within the C terminus of Asf1 is required for its normal function in transcriptional silencing. PMID: 23184661
6. Asf1 and Snf2 function to move kinetically trapped nucleosomes to their energetically favorable sites in promoters PMID: 21508315
7. Saccharomyces cerevisiae Asf1 shields H3/H4 from unfavorable DNA interactions and aids the formation of favorable histone-DNA interactions through the formation of disomes. PMID: 21447559
8. Asf1 stimulates derepression of DNA damage response (DDR) genes during the S phase PMID: 21190944
9. Results suggest that defective chromatin assembly caused by Asf1 leads to double-strand breaks that can be repaired by sister chromatid exchange, affecting genetic stability. PMID: 15071494
10. may have a global role in chromatin disassembly and an unexpected role in histone acetylation in vivo PMID: 15452122
11. ASF1 has a role in activation of the DNA damage checkpoint PMID: 15542840
12. Data indicate that the histone chaperones CAF-1 and Asf1p regulate the gene expression of a broad array of genes in yeast and, in the case of Asf1p, this is likely to be due to a direct role in chromatin modulation during transcriptional regulation. PMID: 15632066
13. ASF1 is required for the recruitment of the SAS histone acetyltransferase complex to the HMLalpha locus. PMID: 15891116
14. Restoration of silencing to CAF-1 subunit cac1 Delta cells requires both Asf1 and Hir1 PMID: 16020781
15. Asf1 blocks formation of the H3-H4 heterotetramer by a mechanism that likely involves occlusion of the H3-H3 dimerization interface PMID: 16229457
16. HIR complex and Asf1 proteins function together as a conserved eukaryotic pathway for histone replacement throughout the cell cycle. PMID: 16303565
17. Together, these data indicate that CAF-1 interacts with H3 methylated at lysine 79 during the processes of epigenetic silencing and DNA repair. PMID: 16503640
18. identified mutations in the nonconserved C terminus of antisilencing function 1 (Asf1) that result in enhanced silencing of HMR and telomere-proximal reporters, overcoming the requirement for CAF-1 in transcriptional silencing PMID: 16582440
19. These data suggest that maintenance of histone H3 lysine 56 acetylation is a primary contribution of Asf1 to genome stability in yeast. PMID: 16627621
20. These results strongly suggest that Asf1 functions as an elongation factor to disassemble and reassemble histones during Pol II elongation. PMID: 16678113
21. Asf1 does not affect the stability of the newly synthesized histones per se, but instead histone binding by Asf1 promotes the efficient acetylation of specific residues of newly synthesized histone H3 PMID: 17107956
22. Asf1 contributes to interpretation of a "histone H3 barcode" for sorting H3 isoforms into different deposition pathways. PMID: 17166288
23. CAF-1 and Asf1 function redundantly to deactivate the checkpoint by restoring chromatin structure on the completion of DNA double-strand break repair. PMID: 19164567
24. Results suggest that the SWI/SNF complex is directly involved in nucleosome removal at HO, and that the histone chaperone Asf1 assists in this during the course of gene regulation. PMID: 19470759
25. ASF1 probably contributes to the maintenance of genome stability through multiple mechanisms, some of which involve the postreplication repair and homologous recombination suppression pathways PMID: 19635810
26. The histone chaperone Rtt106 functions in a pathway with two other chaperones, Asf1 and the HIR complex, to create a repressive chromatin structure at core histone promoters. PMID: 19683497

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KEGG: sce:YJL115W

STRING: 4932.YJL115W