Asic2 Antibody

1. ASICs may enhance susceptibility to epileptogenesis in the piriform cortex. PMID: 25744567
2. identified the expression and localization of different ASIC subunits in the rest and activated microglia and further elucidated the role of ASICs in microglia activation and inflammatory response PMID: 25377529
3. identified domains of ASIC2 that are crucial to channel function and may be important for the function of other members of the ASIC family. PMID: 25583083
4. The aim of this study was to detect the expression of ASIC2 in the nasal septum in the embryonic stage of the rat. PMID: 21566334
5. These results uncover a new mechanism of caspase-8-mediated apoptosis induced by intracellular calcium overload that is dependent on the autophagy-related proteins LC3 and p62 upon hyperactivation of DEG/ENaC channels. PMID: 23239879
6. Acid-sensing ion channels contribute to chemosensitivity of breathing-related neurons of the nucleus of the solitary tract PMID: 22890703
7. Suggest that interaction between ASICs and lactate in the supraoptic nucleus plays an important role in the regulatory mechanism of body fluid homeostasis. PMID: 20442265
8. In the rodent streptozotocin model of diabetes, there are increases in expression of mrna and protein for sodium channels in the suprapotic nucleus. PMID: 12167778
9. ASIC2b is N-terminal splice variant of ASIC2a; RT-PCR analyses confirmed the expression of ASIC2b transcripts in the circumvallate papilla and, moreover, demonstrated its expression in the foliate and fungiform papillae PMID: 12736332
10. ASIC2b has a role in regulation of ASIC3 via the partner protein PICK-1 PMID: 14976185
11. These data suggest that DEG/ENaC proteins are required for vessel responses to pressure and are consistent with the evolutionary conservation of mechanosensory function of DEG/ENaC proteins. PMID: 15381679
12. Acid-sensing ion channel currents are susceptible to regulation by redox agents. (Acid-sensing ion channels) PMID: 16085050
13. ASIC1 and -3 subunits were sensitive to Pb2+. Pb2+ inhibited ASIC currents independent of the amiloride/Ca2+ blockade. PMID: 16319075
14. AKAP150 and the protein phosphatase calcineurin are binding proteins to ASIC2a, and calcineurin regulates ASIC1a and ASIC2a activity PMID: 17548344
15. Vascular smooth muscle ASIC2 is required for normal cell migration. PMID: 17936312
16. ASIC2-Hsc70 interactions may play a role in vascular smooth muscle cell migration and contribute to vasculogenesis and remodeling. PMID: 18310515
17. Results indicate that the proton receptor ASIC2 is expressed in both ciliated and stereociliated cells. PMID: 18560896

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KEGG: rno:25364

UniGene: Rn.37523