asna-1 Antibody

Datasheet

Code	CSB-PA339117XA01CXY
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Target Background

Product Details

Full Product Name

Rabbit anti-Caenorhabditis elegans asna-1 Polyclonal antibody

Uniprot No.

P30632

Target Names

asna-1

Alternative Names

asna-1 antibody; tag-205 antibody; ZK637.5ATPase asna-1 antibody; EC 3.6.-.- antibody; Arsenical pump-driving ATPase antibody; Arsenite-stimulated ATPase antibody

Raised in

Rabbit

Species Reactivity

Caenorhabditis elegans

Immunogen

Recombinant Caenorhabditis elegans asna-1 protein

Immunogen Species

Caenorhabditis elegans

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB (ensure identification of antigen)

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Value-added Deliverables

① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);

Quality Guarantee

① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;

Lead Time

Made-to-order (14-16 weeks)

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Target Background

Function

ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. Subsequently, the homodimer reverts towards the open dimer state, lowering its affinity for the membrane-bound receptor, and returning it to the cytosol to initiate a new round of targeting. May be involved in insulin signaling.

Gene References into Functions

Data show that the parental gene, asna-1, was not targeted by miR-249, presumably because asna-1 is involved in insulin secretion; the cleavage of the asna-1 mRNA might be so detrimental and could be under selective pressure to escape miR-249 targeting. PMID: 23485825
findings show that worms lacking activity of the asna-1 gene arrest growth reversibly at the L1 stage even when food is abundant; proposed that ASNA1 is an evolutionarily conserved modulator of insulin signaling PMID: 17289575
As(III)- & Sb(III)-stimulated ArsA ATPase activities are not restricted to bacteria. asna-1 gene from C. elegans encodes functional ArsA ATPase whose activity is stimulated by As(III) & Sb(III), which is critical for As(III) & Sb(III) tolerance. PMID: 17419726

Subcellular Location

Cytoplasm. Endoplasmic reticulum.

Protein Families

ArsA ATPase family

Database Links

KEGG: cel:CELE_ZK637.5

STRING: 6239.ZK637.5

UniGene: Cel.9540

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Service

Phage Display Service

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Protein Service

Gene Synthesis Service

Oligo Synthesis Service

Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Call us

301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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asna-1 Antibody

Product Details

Related Products

Customer Reviews and Q&A

Target Background