ASNA Antibody

Datasheet
Code CSB-PA757110XA01DIL
Product Type Polyclonal Antibody
Uniprot No. Q6IQE5
Delivery Make-to-order
Protocols ELISA Protocol
Immunogen Recombinant Danio rerio (Zebrafish) (Brachydanio rerio) ASNA protein
Raised in Rabbit
Species Reactivity Danio rerio (Zebrafish) (Brachydanio rerio)
Tested Applications ELISA, WB (ensure identification of antigen)
Form Liquid
Conjugate Non-conjugated
Storage Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Purification Method Protein A/G
Isotype IgG
Clonality Polyclonal
Alias ATPase asna1 (EC 3.6.-.-) (Arsenical pump-driving ATPase) (Arsenite-stimulated ATPase) asna1 si:dkey-121b10.2 zgc:86799
Immunogen Species Danio rerio (Zebrafish) (Brachydanio rerio)
Gene Names asna1
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. Subsequently, the homodimer reverts towards the open dimer state, lowering its affinity for the membrane-bound receptor, and returning it to the cytosol to initiate a new round of targeting.
Subcellular Location Cytoplasm, Endoplasmic reticulum
Protein Families ArsA ATPase family
Database Links

KEGG: dre:325704

STRING: 7955.ENSDARP00000018158

UniGene: Dr.75724

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