ATAT Antibody

Datasheet
Code CSB-PA764799XA01DIL
Product Type Polyclonal Antibody
Uniprot No. Q6PH17
Delivery Make-to-order
Protocols ELISA Protocol
Immunogen Recombinant Danio rerio (Zebrafish) (Brachydanio rerio) ATAT protein
Raised in Rabbit
Species Reactivity Danio rerio (Zebrafish) (Brachydanio rerio)
Tested Applications ELISA, WB (ensure identification of antigen)
Form Liquid
Conjugate Non-conjugated
Storage Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Purification Method Protein A/G
Isotype IgG
Clonality Polyclonal
Alias Alpha-tubulin N-acetyltransferase 1 (Alpha-TAT) (Alpha-TAT1) (TAT) (EC 2.3.1.108) (Acetyltransferase mec-17 homolog) atat1 mec17 si:ch211-152p11.5 zgc:65893
Immunogen Species Danio rerio (Zebrafish) (Brachydanio rerio)
Gene Names atat1
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function Specifically acetylates 'Lys-40' in alpha-tubulin on the lumenal side of microtubules. Promotes microtubule destabilization and accelerates microtubule dynamics; this activity may be independent of acetylation activity. Acetylates alpha-tubulin with a slow enzymatic rate, due to a catalytic site that is not optimized for acetyl transfer. Enters the microtubule through each end and diffuses quickly throughout the lumen of microtubules. Acetylates only long/old microtubules because of its slow acetylation rate since it does not have time to act on dynamically unstable microtubules before the enzyme is released. May be involved in neuron development. Acetylates alpha-tubulin in neurons, but not in cilia.
Subcellular Location Cytoplasm, Membrane, clathrin-coated pit, Cell junction, focal adhesion, Cell projection, axon, Cytoplasm, cytoskeleton, Cytoplasm, cytoskeleton, spindle
Protein Families Acetyltransferase ATAT1 family
Database Links

KEGG: dre:406389

STRING: 7955.ENSDARP00000049367

UniGene: Dr.6427

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