mec-17 Antibody

Datasheet

Code	CSB-PA526136XA01CXY
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Target Background

Product Details

Full Product Name

Rabbit anti-Caenorhabditis elegans mec-17 Polyclonal antibody

Uniprot No.

O45100

Target Names

mec-17

Alternative Names

mec-17 antibody; F57H12.7Alpha-tubulin N-acetyltransferase 1 antibody; Alpha-TAT 1 antibody; TAT 1 antibody; EC 2.3.1.108 antibody; Mechanosensory abnormality protein 17 antibody

Raised in

Rabbit

Species Reactivity

Caenorhabditis elegans

Immunogen

Recombinant Caenorhabditis elegans mec-17 protein

Immunogen Species

Caenorhabditis elegans

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB (ensure identification of antigen)

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Value-added Deliverables

① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);

Quality Guarantee

① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;

Lead Time

Made-to-order (14-16 weeks)

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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Target Background

Function

Specifically acetylates 'Lys-40' in alpha-tubulin/mec-12 on the lumenal side of microtubules. Promotes microtubule destabilization and accelerates microtubule dynamics; this activity may be independent of acetylation activity. Acetylates alpha-tubulin with a slow enzymatic rate, due to a catalytic site that is not optimized for acetyl transfer. Enters the microtubule through each end and diffuses quickly throughout the lumen of microtubules. Acetylates only long/old microtubules because of its slow acetylation rate since it does not have time to act on dynamically unstable microtubules before the enzyme is released. Required for the maintenance of touch receptor neurons and possibly other type of neurons involved in locomotion.

Gene References into Functions

Loss of MEC-17 affects microtubule dynamics, axonal transport and causes axonal degeneration. PMID: 24373971
MEC-17 allows the production of 15-protofilament microtubules in touch receptor neurons. PMID: 22658602
Study shows that MEC-17, a protein related to the Gcn5 histone acetyltransferases4 and required for the function of touch receptor neurons in Caenorhabditis elegans. PMID: 20829795

Protein Families

Acetyltransferase ATAT1 family

Tissue Specificity

Expressed solely in touch receptor neurons.

Database Links

KEGG: cel:CELE_F57H12.7

STRING: 6239.F57H12.7

UniGene: Cel.12810

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Email: [email protected]
Distributors Worldwide

Service

Phage Display Service

Antibody Service

Protein Service

Gene Synthesis Service

Oligo Synthesis Service

Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Call us

301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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mec-17 Antibody

Product Details

Related Products

Customer Reviews and Q&A

Target Background