atat-2 Antibody

Code CSB-PA638737XA01CXY
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Product Details

Full Product Name
Rabbit anti-Caenorhabditis elegans atat-2 Polyclonal antibody
Uniprot No.
Target Names
atat-2
Alternative Names
atat-2 antibody; W06B11.1 antibody; Alpha-tubulin N-acetyltransferase 2 antibody; Alpha-TAT 2 antibody; TAT 2 antibody; EC 2.3.1.108 antibody; Mec-17-like protein antibody
Raised in
Rabbit
Species Reactivity
Caenorhabditis elegans
Immunogen
Recombinant Caenorhabditis elegans atat-2 protein
Immunogen Species
Caenorhabditis elegans
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
Specifically acetylates 'Lys-40' in alpha-tubulin/mec-12 on the lumenal side of microtubules. Promotes microtubule destabilization and accelerates microtubule dynamics; this activity may be independent of acetylation activity. Acetylates alpha-tubulin with a slow enzymatic rate, due to a catalytic site that is not optimized for acetyl transfer. Enters the microtubule through each end and diffuses quickly throughout the lumen of microtubules. Acetylates only long/old microtubules because of its slow acetylation rate since it does not have time to act on dynamically unstable microtubules before the enzyme is released. Required for the maintenance of touch receptor neurons and possibly other type of neurons involved in locomotion.
Protein Families
Acetyltransferase ATAT1 family
Tissue Specificity
Expressed in touch receptor neurons and in a subset of ciliated neurons, including PDE, ADE, CEP, and OLQ neurons.
Database Links

KEGG: cel:CELE_W06B11.1

STRING: 6239.W06B11.1

UniGene: Cel.19790

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