DRS2 Antibody

1. Deletion of KES1 suppresses plasma membrane-missorting defects and the accumulation of intracellular ergosterol in drs2 mutants. PMID: 26466678
2. Imh1p and Drs2p modulate the activity of Gcs1p by timing its interaction with Arl1p, hence providing feedback regulation of Arl1p activity. PMID: 24706946
3. Auto-inhibition of Drs2p, a yeast phospholipid flippase, by its carboxyl-terminal tail. PMID: 24045945
4. results demonstrate that activated Arl1p can promote the spatial modulation of membrane organization at the trans-Golgi network through interacting with the effectors Gea2p and Drs2p PMID: 23345439
5. Cdc50p, a membrane protein in the endosomal/trans-Golgi network compartments, is a noncatalytic subunit of Drs2p, which is implicated in translocation of phospholipids across lipid bilayers. PMID: 16195350
6. Drs2p is an essential endocytic cargo in cells compromised for Ub-dependent endocytosis. PMID: 17122361
7. Potential phospholipid translocases in the Drs2/Dnf family (type IV P-type ATPases [P4-ATPases]) are downstream targets of Kes1p repression. PMID: 19403696
8. the affinity of yeast P(4)-ATPase Drs2p for its Cdc50-binding partner fluctuates during the transport cycle, with the strongest interaction occurring at a point where the enzyme is loaded with phospholipid ligand PMID: 19411703
9. Drs2p can catalyze phospholipid translocation directly through purification and reconstitution of this P4-ATPase into proteoliposomes. PMID: 19805341
10. Drs2p, a type IV P-type ATPase required for phospholipid translocase (flippase) activity and transport vesicle budding from the trans-Golgi network, is an effector of phosphatidylinositol-4-phosphate. PMID: 19898464

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KEGG: sce:YAL026C

STRING: 4932.YAL026C