Atf3 Antibody

Code CSB-PA112956XA01DLU
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Product Details

Full Product Name
Rabbit anti-Drosophila melanogaster (Fruit fly) Atf3 Polyclonal antibody
Uniprot No.
Target Names
Atf3
Alternative Names
Atf3 antibody; A3-3 antibody; CG11405Activating transcription factor 3 antibody
Raised in
Rabbit
Species Reactivity
Drosophila melanogaster (Fruit fly)
Immunogen
Recombinant Drosophila melanogaster (Fruit fly) Atf3 protein
Immunogen Species
Drosophila melanogaster (Fruit fly)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Protein A/G
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
Transcription factor which binds to the cAMP response element (CRE). Regulates metabolic and innate immune homeostasis, possibly by controlling appropriate expression of genes involved in peritrophic matrix composition and ensuring the normal digestive and immune function of the gut. Required for the expression of odorant receptors Or43b and Or47b.
Gene References into Functions
  1. provide a mechanism to explain how an ATF3-Raw module controls JNK signalling to maintain normal intestinal barrier function during acute infection PMID: 28272390
  2. Atf3 controls the microtubule network and plays important role in cell differentiation and cell polarity. PMID: 29494583
  3. Loss of Atf3 results in chronic inflammation and starvation responses mounted primarily by the larval gut epithelium, while the fat body suffers lipid overload, causing energy imbalance and death. PMID: 22851689
Subcellular Location
Nucleus.
Protein Families
BZIP family, ATF subfamily
Tissue Specificity
Moderate expression in some regions of the larval nervous system, the ring gland and imaginal disks. High expression in larval gut, excretory malpighian tubules, salivary glands, and, to a lesser extent, the fat body where levels are approximately 2.5-fol
Database Links
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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
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Address
7505 Fannin St., Ste 610, Room 322 (CUBIO Innovation Center), Houston, TX 77054, USA
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