tel1 Antibody

Datasheet

Code	CSB-PA525594XA01SXV
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Product Details

Full Product Name

Rabbit anti-Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) tel1 Polyclonal antibody

Uniprot No.

O74630

Target Names

tel1

Alternative Names

tel1 antibody; SPCC23B6.03cSerine/threonine-protein kinase tel1 antibody; EC 2.7.11.1 antibody; ATM homolog antibody; DNA-damage checkpoint kinase tel1 antibody; Telomere length regulation protein 1 antibody

Raised in

Rabbit

Species Reactivity

Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)

Immunogen

Recombinant Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) tel1 protein

Immunogen Species

Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB (ensure identification of antigen)

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Value-added Deliverables

① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);

Quality Guarantee

① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;

Lead Time

Made-to-order (14-16 weeks)

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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Target Background

Function

Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, involved in the regulation of DNA damage response mechanism. Undirectly involved in the phosphorylation of rad32 which is necessary for its telomere function. Required for the control of telomere length and genome stability.

Gene References into Functions

The structure suggests that ataxia-telangiectasia mutated protein (ATM/Tel1) dimer interface and the consecutive HEAT repeats inhibit the binding of kinase substrates and regulators by steric hindrance. PMID: 27229179
It is a DNA damage sensor kinases and plays a roll in telomere maintenance. PMID: 25675824
Tel1(ATM)/Rad3(ATR)-dependent Ccq1 Thr93 phosphorylation is a critical regulator of telomere maintenance in fission yeast. PMID: 22101932
The N-terminus of Nbs1 contributes to the recruitment of Rad3(ATR)-Rad26(ATRIP) to telomeres. PMID: 20140190
Recombination-based telomere maintenance is dependent on Tel1 and Rap1 and inhibited by telomerase, Taz1, and Ku. PMID: 18160711
Tel1 and Rad3 are required for both protection of telomeres against recombination and promotion of telomerase recruitment. PMID: 19714219

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Subcellular Location

Nucleus. Chromosome, telomere.

Protein Families

PI3/PI4-kinase family, ATM subfamily

Database Links

KEGG: spo:SPCC23B6.03c

STRING: 4896.SPCC23B6.03c.1

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Email: [email protected]
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Service

Phage Display Service

Antibody Service

Protein Service

Gene Synthesis Service

Oligo Synthesis Service

Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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tel1 Antibody

Product Details

Related Products

Customer Reviews and Q&A

Target Background