ATP6 Antibody

Code CSB-PA015070XA01SVG
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Product Details

Full Product Name
Rabbit anti-Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) ATP6 Polyclonal antibody
Uniprot No.
Target Names
ATP6
Alternative Names
ATP6; OLI2; OLI4; PHO1; Q0085; ATP synthase subunit a; F-ATPase protein 6
Raised in
Rabbit
Species Reactivity
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Immunogen
Recombinant Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) ATP6 protein
Immunogen Species
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Key component of the proton channel; it may play a direct role in the translocation of protons across the membrane.
Gene References into Functions
  1. The T9185C and T9191C ATP synthase two pathogenic human mitochondrial DNA mutations correlate with the severity phenotypes of two mitochondrial human diseases. PMID: 24316278
  2. analysis of the structure of the yeast F1Fo-ATP synthase dimer and its role in shaping the mitochondrial cristae PMID: 22864911
  3. two subunits 6 are close in the inner mitochondrial membrane and in the solubilized supramolecular forms of the yeast ATP synthase. PMID: 21868388
  4. Although the oxidative phosphorylation capacity was reduced in atp6-T9176C yeast, the number of ATP molecules synthesized per electron transferred to oxygen was similar compared with wild type yeast. PMID: 20056103
  5. atp6 mutant exhibited unusual mitochondrial structure and distribution anomalies PMID: 17261589
  6. Mitochondrial morphology is profoundly altered in the human mutant atp6-L247R. PMID: 19454486

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Subcellular Location
Mitochondrion inner membrane; Multi-pass membrane protein.
Protein Families
ATPase A chain family
Database Links

KEGG: sce:Q0085

STRING: 4932.Q0085

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