nrv2 Antibody

Code CSB-PA636544XA01DLU
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Product Details

Full Product Name
Rabbit anti-Drosophila melanogaster (Fruit fly) nrv2 Polyclonal antibody
Uniprot No.
Target Names
nrv2
Alternative Names
nrv2 antibody; CG9261Sodium/potassium-transporting ATPase subunit beta-2 antibody; Protein nervana 2 antibody; Sodium/potassium-dependent ATPase subunit beta-2 antibody
Raised in
Rabbit
Species Reactivity
Drosophila melanogaster (Fruit fly)
Immunogen
Recombinant Drosophila melanogaster (Fruit fly) nrv2 protein
Immunogen Species
Drosophila melanogaster (Fruit fly)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane.
Gene References into Functions
  1. Knocking down nrv2 in scolopale cells blocked Nrv2 expression, reduced ATPalpha expression in the scolopale cells, and caused almost complete deafness. PMID: 23248276
  2. Gene expression of the beta-subunit of Na+/K+-ATPase were slightly clock-controlled. PMID: 19428365
Subcellular Location
Cell membrane; Single-pass type II membrane protein.
Protein Families
X(+)/potassium ATPases subunit beta family
Tissue Specificity
In embryos, it is expressed in the neurons of the CNS and PNS, in Garland cells and posterior spiracles. In adults, it shows a nervous system specific distribution: optic lobes, brain, thoracic ganglia and axonal pathways in the leg. Both isoforms concent
Database Links

KEGG: dme:Dmel_CG9261

STRING: 7227.FBpp0079009

UniGene: Dm.4056

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