Product Details

Full Product Name

Rabbit anti-Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TIM11 Polyclonal antibody

Uniprot No.

P81449

Target Names

TIM11

Alternative Names

TIM11 antibody; ATP21 antibody; YDR322C-A antibody; YDR322BCATP synthase subunit e antibody; mitochondrial antibody; ATPase subunit e antibody; Translocase of the inner membrane protein 11 antibody

Raised in

Rabbit

Species Reactivity

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)

Immunogen

Recombinant Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) TIM11 protein

Immunogen Species

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB (ensure identification of antigen)

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Value-added Deliverables

① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);

Quality Guarantee

① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;

Lead Time

Made-to-order (14-16 weeks)

Target Background

Function

Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane.

Gene References into Functions

The authors report that subunit e of the F1Fo-ATP synthase, a small single-spanning inner membrane protein that is critical for inner membrane organization, is imported by TIM23 in a process that does not require activation by the membrane potential. PMID: 26827728
Data show that Su k (Atp19) and Su i (Atp18) are involved in the assembly of Su e (Atp21) and Su g (Atp20) F(1)F(o)-ATP synthase dimers and oligomers. PMID: 20219971
Results show that the N-terminal hydrophobic region plays important roles in the F1Fo-ATP synthase subunit e-dependent processes of mitochondrial DNA maintenance, modulation of mitochondrial morphology, and stabilization of the dimer-specific Fo subunits. PMID: 15701797
the GXXXG motif may not be the sole basis for a Su g-Su e interaction within F1F0-ATPase PMID: 15886192
Results propose a model in which the antagonism between Fcj1 and Su e/g locally modulates the F(1)F(O) oligomeric state, thereby controlling membrane curvature of cristae to generate crista junctions and cristae tips. PMID: 19528297
Association of Su e and Su g with monomeric F(1)F(o)-ATP synthase represents an initial step of oligomer formation. PMID: 19635484

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Subcellular Location

Mitochondrion. Mitochondrion inner membrane.

Database Links

KEGG: sce:YDR322C-A

STRING: 4932.YDR322C-A

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TIM11 Antibody

Product Details

Customer Reviews and Q&A

Target Background