atx-3 Antibody

Code CSB-PA519441XA01CXY
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Product Details

Full Product Name
Rabbit anti-Caenorhabditis elegans atx-3 Polyclonal antibody
Uniprot No.
Target Names
atx-3
Alternative Names
atx-3 antibody; F28F8.6Ataxin-3 homolog antibody; EC 3.4.19.12 antibody; Machado-Joseph disease-like protein antibody
Raised in
Rabbit
Species Reactivity
Caenorhabditis elegans
Immunogen
Recombinant Caenorhabditis elegans atx-3 protein
Immunogen Species
Caenorhabditis elegans
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
Acts as chain editing deubiquitinating enzyme that binds and cleaves 'Lys-48'-linked polyubiquitin chains, with a preference for chains containing four or more ubiquitin molecules thereby modulating protein degradation by the ubiquitin-proteasome pathway. Probably by regulating the IGF-1-insulin-like pathway, regulates lifespan. Regulates germline DNA double-strand-break repair and apoptosis in response to DNA damage by recruiting E4 ubiquitin-protein ligase ufd-2 to DNA repair foci. Interacts with key regulators of transcription and represses transcription. Acts as a histone-binding protein that regulates transcription.
Gene References into Functions
  1. ATX-3 is a Machado-Joseph disease deubiquitylase that couples longevity and proteostasis PMID: 21317884
  2. ataxin-3 has a role in regulating core sets of genes involved in the ubiquitin-proteasome pathway, structure/motility, and signal transduction PMID: 17234717
Subcellular Location
Cytoplasm. Nucleus. Nucleus, nucleolus.
Tissue Specificity
Expressed in germline (at protein level). Expressed in spermatheca, pharynx, dorsal and ventral cords, some head neurons, hypodermis, body wall muscles and coelomocytes.
Database Links

KEGG: cel:CELE_F28F8.6

STRING: 6239.F28F8.6.1

UniGene: Cel.6510

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