BB Antibody

Datasheet

Code	CSB-PA813148XA01DOA
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Product Details

Full Product Name

Rabbit anti-Arabidopsis thaliana (Mouse-ear cress) BB Polyclonal antibody

Uniprot No.

Q8L649

Target Names

Alternative Names

BB antibody; EOD1 antibody; At3g63530 antibody; TEL3S.1E3 ubiquitin-protein ligase BIG BROTHER antibody; EC 2.3.2.27 antibody; Protein ENHANCER OF DA1-1 antibody; RING-type E3 ubiquitin transferase BIG BROTHER antibody

Raised in

Rabbit

Species Reactivity

Arabidopsis thaliana

Immunogen

Recombinant Arabidopsis thaliana BB protein

Immunogen Species

Arabidopsis thaliana (Mouse-ear cress)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB (ensure identification of antigen)

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Value-added Deliverables

① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);

Quality Guarantee

① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;

Lead Time

Made-to-order (14-16 weeks)

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Target Background

Function

E3 ubiquitin-protein ligase that limits organ size, and possibly seed size, in a dose-dependent manner. Negatively regulates the duration of cell proliferation in leaves and petals independently of the major phytohormones (e.g. auxin, cytokinin, gibberellin, brassinosteroids, ethylene, abscisic acid, jasmonic acid), probably by targeting growth stimulators for degradation. Limits the proliferation of root meristematic cells. Polyubiquitinates DA1. Involved in the promotion of leaf senescence, in addition to its function in restricting plant growth. Possesses E3 ubiquitin-protein ligase activity in vitro.

Gene References into Functions

BB acts conceptually similarly in leaf(-like) organs and the primary root, and uncouples cell proliferation from elongation in the root meristem. PMID: 28922745
Big brother protein role in controlling leaf growth and senescence PMID: 28003326
Genetic analyses show that DA2 functions synergistically with DA1 to regulate seed size, but does so independently of EOD1. Further results reveal that DA2 interacts physically with DA1 in vitro and in vivo. PMID: 24045020
Conserved cis-elements are important for regulation of BB expression. PMID: 22433627
The E3 ubiquitin ligase BIG BROTHER controls arabidopsis organ size in a dosage-dependent manner. PMID: 16461280

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Tissue Specificity

Mostly expressed in inflorescence, and, to a lower extent, in seedlings, roots, stems, leaves and siliques.

Database Links

KEGG: ath:AT3G63530

STRING: 3702.AT3G63530.1

UniGene: At.44049

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BB Antibody

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