Product Details

Full Product Name

Rabbit anti-Caenorhabditis elegans bec-1 Polyclonal antibody

Uniprot No.

Q22592

Target Names

bec-1

Alternative Names

bec-1 antibody; atg-6 antibody; T19E7.3Beclin homolog antibody

Raised in

Rabbit

Species Reactivity

Caenorhabditis elegans

Immunogen

Recombinant Caenorhabditis elegans bec-1 protein

Immunogen Species

Caenorhabditis elegans

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB (ensure identification of antigen)

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Value-added Deliverables

① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);

Quality Guarantee

① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;

Lead Time

Made-to-order (14-16 weeks)

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Target Background

Function

Regulates autophagy. Together with phosphatidyl-3-phosphate kinase vps-34, acts as a core subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate (PtdIns3P), thereby regulating membrane trafficking. In association with sorf-1 and sorf-2, negatively regulates phosphatidylinositol 3-phosphate in early endosomes to allow for the conversion to late endosomes. Involved in the clearance of engulfed apoptotic cell corpses. Together with ced-9, negatively regulates somatic and germline apoptosis. Plays a role in endosome-to-Golgi retrograde transport of mig-14. In a daf-18/PTEN- and skn-1/Nrf-dependent manner, promotes germline stem cell proliferation during late and adult stages, probably by ensuring cell survival and cell cycle progression. Required for embryonic development and L3/L4 molting during larval development. Required for normal dauer morphogenesis and lifespan. Plays a role in male tail ray pattern formation. Required for normal survival when exposed to pathogenic bacteria S.typhimurium by promoting autophagic degradation of intracellular S.typhimurium.

Gene References into Functions

The authors' findings demonstrate a novel non-autonomous role for BEC-1/BECN1/Beclin1 in the control of stem cell proliferation and cell-cycle progression, which may have implications for the understanding and development of therapies against malignant cell growth in the future. PMID: 28285998
mutants in the gene bec-1 (VPS30/ATG6/BECN1), a key regulator of autophagy, failed to store substantial neutral lipids in their intestines during development PMID: 23321914
Atg6/Vps30/Beclin 1 ortholog BEC-1 mediates endocytic retrograde transport in addition to autophagy in C. elegans PMID: 21183797
essential for normal dauer morphogenesis and life-span extension PMID: 12958363
BEC-1 is necessary for the function of the class III PI3 kinase LET-512/Vps34, forms a complex with the antiapoptotic protein CED-9/Bcl-2, and its depletion triggers CED-3/Caspase-dependent programmed cell death. PMID: 16111945
bec-1 is an essential autophagy gene required for the longevity phenotype of the C. elegans dietary restriction mutant animal. PMID: 17912023

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Subcellular Location

Cytoplasm. Perikaryon. Cell projection, dendrite. Cell projection, axon. Endosome.

Protein Families

Beclin family

Tissue Specificity

Expressed in PVM touch receptor neurons, the ventral nerve cord and in the nerve ring.

Database Links

KEGG: cel:CELE_T19E7.3

STRING: 6239.T19E7.3.2

UniGene: Cel.12317

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bec-1 Antibody

Product Details

Customer Reviews and Q&A

Target Background