BIG Antibody

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Code	CSB-PA886755XA01DOA
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Target Background

Product Details

Full Product Name

Rabbit anti-Arabidopsis thaliana (Mouse-ear cress) BIG Polyclonal antibody

Uniprot No.

Q9SRU2

Target Names

BIG

Alternative Names

BIG antibody; ASA1 antibody; CRM1 antibody; DOC1 antibody; GA6 antibody; LPR1 antibody; TIR3 antibody; UMB1 antibody; At3g02260 antibody; F14P3.9Auxin transport protein BIG antibody; Protein ATTENUATED SHADE AVOIDANCE 1 antibody; Protein CORYMBOSA1 antibody; Protein DARK OVER-EXPRESSION OF CAB 1 antibody; Protein LOW PHOSPHATE-RESISTANT ROOT 1 antibody; Protein TRANSPORT INHIBITOR RESPONSE 3 antibody; Protein UMBRELLA 1 antibody

Raised in

Rabbit

Species Reactivity

Arabidopsis thaliana

Immunogen

Recombinant Arabidopsis thaliana BIG protein

Immunogen Species

Arabidopsis thaliana (Mouse-ear cress)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB (ensure identification of antigen)

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Value-added Deliverables

① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);

Quality Guarantee

① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;

Lead Time

Made-to-order (14-16 weeks)

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Target Background

Function

Required for auxin efflux and polar auxin transport (PAT) influencing auxin-mediated developmental responses (e.g. cell elongation, apical dominance, lateral root production, inflorescence architecture, general growth and development). Controls the elongation of the pedicels and stem internodes through auxin action. Involved in the expression modulation of light-regulated genes. Represses CAB1 and CAB3 genes expression in etiolated seedlings. Confers sensitivity to the auxin transport inhibitors N-1-naphthylphthalamic acid (NPA), 2-carboxyphenyl-3-phenylpropane-l,2-dione (CPD), and methyl-2-chloro-9-hydroxyfluorene-9-carboxylate (CFM). Influences the polarized subcellular distribution of the auxin transporter PIN1 in response to auxin transport inhibitors. Plays a role in the regulation of responses to phytohormones such as auxin, cytokinins, ethylene and gibberellic acid (GA), particularly during light-mediated stimuli (e.g. shade ovoidance, etiolation). Required for pericycle cell activation to form lateral root primordia (LRP) in both high and low phosphate P conditions. Necessary for the plant-growth promotion and lateral root development mediated by the fungus Trichoderma virens.

Gene References into Functions

The crm1 mutants had defects in cell division and elongation. Auxin signaling and cell cycle gene expression in crm1 inflorescences were lower than those in the wild type ...mutants defective in auxin signaling had shorter pedicels and internodes... PMID: 23759104
required for organ growth via auxin action PMID: 23288076
BIG is required for pericycle cell activation to form LRP in both high and low phosphate conditions, but not for the low P-induced alterations in primary root growth, lateral root emergence, and root hair elongation. PMID: 15681664
results suggest that CRM1/BIG controls the elongation of the pedicels and stem internodes through auxin action PMID: 17652113

Subcellular Location

Membrane; Multi-pass membrane protein.

Protein Families

UBR4 family

Tissue Specificity

Constitutively expressed in roots, rosette leaves, inflorescence stems, and flowers. Present in inflorescence meristems, floral meristems and vascular tissues.

Database Links

KEGG: ath:AT3G02260

STRING: 3702.AT3G02260.1

UniGene: At.46446

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BIG Antibody

Product Details

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Customer Reviews and Q&A

Target Background