birA Antibody

1. BirA signals to the global regulator Fur, which in turn activates LEE (locus of enterocyte effacement) genes to promote EHEC adherence in the low-biotin large intestine. PMID: 25791315
2. work demonstrates that variable surface loops evolved to support BirA function in the homodimerization required for transcription repression by complementing the constant loops, which are constrained because of their essential role in posttranslational biotin addition PMID: 22446587
3. BirA function entails extensive interactions among the three domains of the protein and show that normal ligase activity does not ensure normal DNA binding. PMID: 22210766
4. Results describe the 2.8A resolution crystal structure of BirA in complex with the co-repressor analog biotinol-5'-AMP. PMID: 16438984
5. Results indicate that the hydrophobic cluster is critical to the ligand-induced disorder-to-order transition in birA and that this transition is integral to the allosteric response in the biotin repressor. PMID: 17765263
6. BirA ligase biotinylates K4, K9, K18 and K23 in histone H3. PMID: 18452652
7. energetic and structural underpinnings of the dual specificity of protein BirA as a homodimer or as a heterodimer with acetyl coenzyme A carboxylase PMID: 19361526

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KEGG: ecj:JW3941

STRING: 316385.ECDH10B_4162