Blm Antibody

1. Study shows that meiotic crossover patterning is lost in Drosophila melanogaster mutants that lack the Bloom syndrome helicase. PMID: 27989672
2. Blm helicase function plays a role in homologous recombination. Blm is not required for suppression of recombination between diverged sequences. PMID: 28912341
3. Dme-miR-314-3p modulation in Cr(VI) exposed Drosophila affects DNA damage repair by targeting mus309 PMID: 26590872
4. Drosophila BLM suppresses error-prone alternative end-joining repair of DNA double-strand breaks that can result in genome instability and tumor formation during aging. PMID: 22183041
5. these studies of synthetic lethality provide insights into the multiple functions of DmBLM and how various endonucleases may function when DmBLM is absent PMID: 22022278
6. Data show that excision screens in mus309 mutant flies that lack DmBlm increases the percentage and overall size of flanking deletions recovered after excision of either P or Minos elements. PMID: 19687136
7. Coding sequence of Ku70 gene is wild-type in two mus309 mutant lines. PMID: 12206368
8. results suggest a model in which BLM maintains genomic stability by promoting efficient repair DNA synthesis and thereby prevents double-strand break repair by less precise pathways PMID: 12522255
9. model in which DmBlm acts downstream of strand invasion to unwind a D-loop intermediate to free the newly synthesized strand PMID: 15501916
10. Blm mutants are defective for homologous repair but show a compensating increase in single-strand annealing. PMID: 17075047
11. DmBLM combines DNA strand displacement with DNA strand annealing to catalyze the displacement of one DNA strand while annealing a second complementary DNA strand. PMID: 17272294
12. Mutations that delete the N terminus of DmBlm, but not the helicase domain, have DSB repair defects as severe as those caused by null mutations. PMID: 17507683
13. mutations in mus81 and mms4 are synthetically lethal with null mutations in mus309 PMID: 17603121
14. The suppression of homeologous single strand annealing depends on the Bloom helicase (Blm), encoded by the Drosophila gene mus309. PMID: 18978019

Show More

Hide All

KEGG: dme:Dmel_CG6920

STRING: 7227.FBpp0081910

UniGene: Dm.2444