BMH2 Antibody

1. Lack of 14-3-3 proteins in Saccharomyces cerevisiae results in cell-to-cell heterogeneity in the expression of Pho4-regulated genes SPL2 and PHO84 PMID: 28877665
2. Both Bmh1 and Bmh2 associate with the promoters of at least some of these genes. BMH2, but not BMH1, attenuates the repression of genes involved in some functions required for ribosome biogenesis. BMH2 also attenuates the activation of genes sensitive to nitrogen catabolite repression. PMID: 27919033
3. Bmh2 is required for nuclear Gln3 localization and appears to function downstream of Ure2. PMID: 28007891
4. demonstrated the interaction of Rod1 with Hxt6 and showed that the localization of the Rod1-Hxt6 complex at the plasma membrane is affected by carbon source and is reduced upon overexpression of SNF1 and BMH2 PMID: 27261460
5. Data indicate that transcription activation is regulated negatively by two redundant 14-3-3 isoforms, Bmh1 and Bmh2. PMID: 25355315
6. Bmh1 and Bmh2 inhibit transcription by binding to Adr1 at promoters that contain a preinitiation complex, demonstrating that Bmh-mediated inhibition is not due to nuclear exclusion, inhibition of DNA binding, or RNA polymerase II (Pol II) recruitment. PMID: 23207903
7. Yeast BMH1 and BMH2 possess a distinctly variant C-terminal compared to human 14-3-3 zeta protein. PMID: 20384366
8. BMH2 function as essential factors for the assembly and maintenance of the pre-replication complex during G1 phase. PMID: 19934224
9. genome-wide transcription analysis of a temperature-sensitive bmh2 mutant PMID: 15142031
10. high-dosage suppressors of the growth defects of temperature-sensitive bmh1 and bmh2 mutants PMID: 16648583
11. role of 14-3-3 in the trafficking of this multimeric Pmp2p reporter is isoform-specific PMID: 16734667
12. Acm1 and Bmh1/Bmh2 constitute a specialized inhibitor of anaphase-promoting complex/CCdh1. PMID: 17030612
13. The 14-3-3 functional interaction appears to modulate Rad53 activity, reminiscent of 14-3-3's effect on human Raf1 kinase and distinct from the indirect mode of regulation by 14-3-3 observed for Chk1 or Cdc25. PMID: 17299042
14. We propose that Bmh1 and -2 are common regulators of many cell signaling modules and pathways mediated by protein phosphorylation and regulate a variety of biological events by coordinately controlling the identified multiplex phosphoprotein components. PMID: 17559233
15. Nucleocytoplasmic shuttling of Pik1p involves phosphorylation and 14-3-3 proteins bind Pik1p in the cytoplasm. PMID: 18172025

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KEGG: sce:YDR099W

STRING: 4932.YDR099W