5 Antibody

Datasheet

Code	CSB-PA321413XA01EDZ
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Target Background

Product Details

Full Product Name

Rabbit anti-Enterobacteria phage T4 (Bacteriophage T4) 5 Polyclonal antibody

Uniprot No.

P16009

Target Names

Alternative Names

5Baseplate central spike complex protein gp5 antibody; Peptidoglycan hydrolase gp5 antibody; EC 3.2.1.17 antibody; Protein Gp5) [Cleaved into: Gp5*; Gp5C] antibody

Raised in

Rabbit

Species Reactivity

Enterobacteria phage T4 (Bacteriophage T4)

Immunogen

Recombinant Enterobacteria phage T4 (Bacteriophage T4) 5 protein

Immunogen Species

Enterobacteria phage T4 (Bacteriophage T4)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB (ensure identification of antigen)

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Value-added Deliverables

① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);

Quality Guarantee

① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;

Lead Time

Made-to-order (14-16 weeks)

Customer Reviews and Q&A

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Target Background

Function

Baseplate central spike complex-associated lysozyme that is essential for the localized hydrolysis of bacterial cell wall, so that the tail tube, through which the phage DNA is ejected, can penetrate to the host inner membrane. The tail lysozyme complex at the tip of the tail tube penetrates through the outer membrane into the periplasm and during that process, gp5* dissociates from gp5C and activated. Due to the lower pH in the periplasm, gp5* would dissociate from gp27 which probably still binds to the tip of the tube. This way, lysozyme domain is released and locally digests the peptidoglycan layer to make a hole to let the tube penetrate to the inner membrane. Involved in the tail assembly.

Gene References into Functions

Data suggest that the buried binding pocket of lysozyme can be manipulated (here using double mutant L99A/M102Q) to change observed affinity and thus free energy of binding as ligands bind this site. PMID: 25212393
investigation of how the topological organization of T4 lysozyme protein (the order of structural elements along the sequence) affects the coupling and folding cooperativity between its domains PMID: 20495548
the lysozyme is inhibited before gp5 is cleaved and, presumably, the lysozyme is activated only after gp5 has penetrated the outer membrane in the infection of E coli PMID: 15701513
When heated, the resulting (gp5*)3 dissociates into three gp5* and a c-terminal trimeric beta-helical structure. The interaction between gp27 and gp5* during infection is sundered by reducing pH. PMID: 16956798
The paper shows that the protein is flexible and adapts to the size and shape of the halogenated benzene ligands. PMID: 19014950

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Subcellular Location

[Baseplate central spike protein Gp5*]: Virion.; [Gp5C]: Virion.; [Pre-baseplate central spike protein Gp5]: Virion.

Protein Families

Glycosyl hydrolase 24 family

Database Links

KEGG: vg:1258817

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5 Antibody

Product Details

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