br Antibody

Datasheet

Code	CSB-PA255546XA01DLU
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Product Details
Customer Reviews and Q&A
Target Background

Product Details

Full Product Name

Rabbit anti-Drosophila melanogaster (Fruit fly) br Polyclonal antibody

Uniprot No.

Q01295

Target Names

Alternative Names

br antibody; Br-C antibody; CG11491 antibody; Broad-complex core protein isoforms 1/2/3/4/5 antibody

Raised in

Rabbit

Species Reactivity

Drosophila melanogaster (Fruit fly)

Immunogen

Recombinant Drosophila melanogaster (Fruit fly) br protein

Immunogen Species

Drosophila melanogaster (Fruit fly)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB (ensure identification of antigen)

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Value-added Deliverables

① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);

Quality Guarantee

① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;

Lead Time

Made-to-order (14-16 weeks)

Customer Reviews and Q&A

■ Customer Reviews

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Target Background

Function

Broad-complex proteins are required for puffing and transcription of salivary gland late genes during metamorphosis.

Gene References into Functions

broad (br), encoding a small group of zinc-finger transcription factors resulting from alternative splicing, is a transcriptional target of Notch nuclear effector Suppressor of Hairless (Su(H)). PMID: 24815210
Understanding Broad expression is impossible without simultaneously considering two enhancers, a dynamic gradient, and a network with extracellular and intracellular components. PMID: 24127599
Broad (Br)-mediated hormone signaling regulates AMP specification PMID: 23048182
These data show the potential for diverse functions of Broad within the developing central nervous system PMID: 19883497
Broad specifies pupal development and mediates the 'status quo' action of juvenile hormone on the pupal-adult transformation in Drosophila and Manduca. PMID: 11959833
BR-C, the zinc family of transcription factors, is regulated by ecdysone during insect metamorphosis. DRONC caspase is transcriptionally regulated and is essential for ecdysone-mediated cell death. PMID: 12045184
Mutations in the steroid-regulated genes BR-C and E93 differentially impact larval midgut cell death but do not affect the formation of adult midgut epithelia PMID: 12297099
depending upon the period of expression relative to the major peak of ecdysone production, BR-C Z1, Z2, and Z4 first inhibited and then stimulated the process of SG PMID: 12490155
The BR-C Z3 isoform is essential for BhC4-1-lacZ induction in prepupal salivary glands and constitute the first demonstration of the participation of early genes products on DNA puff genes regulation. PMID: 17083105
PP2A-dependent disruption of centrosome replication and cytoskeleton organization by SV40 small tumor antigen is reported. PMID: 18663356
cell-type-selective expression of BRC isoforms suggests a model of BRC-dependent CNS morphogenesis resulting from intercellular interactions, culminating in BRC-Z1-controlled, glia-mediated CNS movements in late prepupa. PMID: 19711379

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Subcellular Location

Nucleus.

Database Links

UniGene: Dm.20757

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