BRE1 Antibody

1. Bre1's function in G1 and S phases contributes to chromatid cohesion establishment, but it is not required for cohesion maintenance in G2 phase. PMID: 29058668
2. By docking onto the NCP surface in this distinct orientation, Bre1 positions the Rad6 active site directly over H2B Lys123. The Spt-Ada-Gcn5 acetyltransferase (SAGA) H2B deubiquitinase module competes with Bre1 for binding to the NCP acidic patch, indicating regulatory control. Our study reveals a mechanism that ensures site-specific NCP ubiquitination and fine-tuning of opposing enzymatic activities PMID: 27601672
3. Rad6-Bre1 pathway regulates both telomere length and recombination through its role in histone H2B lysine 123 mono-ubiquitination PMID: 28180293
4. Results identified Rai1, in regulating early transcription elongation genome-wide and a novel role for the histone modifier, Bre1, in regulating Pol II dynamics at polyA sites. PMID: 28043953
5. Studied structure of C-terminal fragment of yeast Bre1 RING domain. PMID: 25864391
6. Data show that E3 ligase Bre1 RING domain directs ubiquitin-conjugating enzyme E2 Rad6 to monoubiquitinate histone H2B Lys-123. PMID: 25548288
7. inappropriate Bre1 levels lead to defects in gene regulation PMID: 25085417
8. Functional analysis of Bre1p, an E3 ligase for histone H2B ubiquitylation, in regulation of RNA polymerase II association with active genes and transcription in vivo PMID: 23417674
9. DOA1 is important for cell cycle entry by supplying ubiquitin, and the RAD6-BRE1 pathway functions downstream of DOA1/ubiquitin but upstream of CDC28, by promoting transcription of cyclins PMID: 22042866
10. mediates histone H2B ubiquitylation and regulates apoptosis PMID: 20460436
11. histone H2B ubiquitination by Rad6-Bre1 and H3 methylation by Dot1 is an essential component of the DNA damage checkpoint PMID: 15632126
12. and confirm findings of a G1 checkpoint role for the RAD6/BRE1/DOT1 pathway PMID: 16783014
13. A purified yPaf1 complex directly and selectively interacts with yBre1 and thus serves to link the H2B ubiquitylation and general transcription machineries. PMID: 19531475

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KEGG: sce:YDL074C

STRING: 4932.YDL074C