Bst2 Antibody

1. contain the spread of herpes simplex virus type 1 in vivo, STING-dependent signaling leads to the upregulation of tetherin, a viral restriction factor PMID: 26627457
2. Tetherin-mediated retention of R-defective virions on the cell surface could enhance syncytium formation. PMID: 27928916
3. Bone marrow stromal antigen 2-mediated dendritic cell activation as a critical mechanism for how Tetherin influenced retrovirus cell-mediated immune responses that subsequently inhibited retrovirus replication in vivo. PMID: 26846717
4. BST-2 does not have a role in modulating Influenza A Virus in the mouse model of infection PMID: 26566124
5. Although Bst2 prevented Measles virus (MV) release from nonneuronal cells, its deletion had no effect on viral pathogenesis in MV-challenged mice. PMID: 26311886
6. BST-2 contributes to the emergence of neoplasia and malignant progression of breast cancer. BST-2 enhances cancer cell adhesion, anchorage-independency, migration, and invasion. PMID: 25499888
7. BST-2 protects lymphoid tissues from Chikungunya virus (CHIKV) infection and regulates CHIKV-induced inflammatory response by the host. PMID: 25053563
8. TLR4 and PI3K effects on BST-2 induction are at the level of transcription. PMID: 24036213
9. Tetherin acts as a modulator of the cell-mediated immune response against retrovirus infection in vivo. PMID: 24872193
10. These findings suggest that BST2 antagonism by Vpu is critical for efficient early viral expansion and dissemination during acute infection and as such is likely to confer HIV-1 increased transmission fitness. PMID: 24195843
11. These data suggest that overexpression of BST-2 in carcinoma tissues could not be attributed to interferons but to a yet to be determined factor that upregulates BST-2 once oncogenesis is initiated. PMID: 23806386
12. Taken together, our results indicate that BST-2 is an important factor in the invasiveness and motility of tamoxifen-resistant breast cancer cells, and that its expression and activity are regulated by activated STAT3. PMID: 23702480
13. BST-2 is a useful receptor to target with antigen, given its broad expression pattern and ability to access both MHCI and MHCII presentation pathways with relative efficiency. PMID: 23303646
14. A single nucleotide polymorphism in tetherin promotes retrovirus restriction in vivo. PMID: 22457621
15. find that tetherin markedly inhibits the replication of Moloney murine leukemia virus (Mo-MLV) and is required for the antiretroviral activity of IFNalpha to be fully manifested in vitro. PMID: 22025715
16. These data provide evidence that BST-2 restricts mouse mammary tumor virus release from naturally infected cells and that BST-2 is an antiviral factor in vivo. PMID: 22284121
17. These findings reflect involvement of BST2 in endocytosis and intracellular trafficking of viruses, viral nucleic acids, and Ags. PMID: 22327075
18. Tetherin is expressed on the plasma membrane outer face of neuroblastoma cells, can be induced with both IFN-gamma & IFN-beta, & restricts progeny VSV release up to 100-fold, contributing to a potent antiviral state in the host cell. PMID: 21919738
19. BST2-mediated Ag delivery in the presence of polyinosinic-polycytidylic acid as adjuvant induces cytotoxic T lymphocytes that are functional in vivo PMID: 21555533
20. Structural and biophysical analysis of BST-2/tetherin ectodomains reveals an evolutionary conserved design to inhibit virus release. PMID: 21084286
21. Elevated cellular levels of BST-2 inhibited the release of virus-like particles consisting of the matrix proteins of multiple highly virulent NIAID Priority Pathogens PMID: 20686043
22. Targeting BST-2 with 2 independent monoclonal antibodies delayed lymphoma growth in a syngeneic mouse model of the disease. PMID: 19903902
23. BST2 resides within an intracellular compartment corresponding to the Golgi apparatus, and may be involved in trafficking secreted cytokines in type I IFN-producing cells PMID: 16920966

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KEGG: mmu:69550

STRING: 10090.ENSMUSP00000051921

UniGene: Mm.260325