C166A Antibody

Datasheet
Code CSB-PA845859XA01DIL
Product Type Polyclonal Antibody
Uniprot No. Q90460
Delivery Make-to-order
Immunogen Recombinant Danio rerio (Zebrafish) (Brachydanio rerio) C166A protein
Raised in Rabbit
Species Reactivity Danio rerio (Zebrafish) (Brachydanio rerio)
Tested Applications ELISA, WB (ensure identification of antigen)
Form Liquid
Conjugate Non-conjugate
Storage Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Purification Method Protein A/G
Isotype IgG
Clonality Polyclonal
Alias CD166 antigen homolog A (Activated leukocyte cell adhesion molecule A) (DM-GRASP homolog) (Neurolin) (CD antigen CD166) alcama alcam cd166
Immunogen Species Danio rerio (Zebrafish) (Brachydanio rerio)
Protocols ELISA Protocol
Gene Names alcama
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function Cell adhesion molecule that mediates both heterotypic cell-cell contacts via its interaction with CD6, as well as homotypic cell-cell contacts. Promotes T-cell activation and proliferation via its interactions with CD6 (By similarity). Contributes to the formation and maturation of the immunological synapse via its interactions with CD6 (By similarity). Mediates homotypic interactions with cells that express ALCAM. Mediates attachment of dendritic cells onto endothelial cells via homotypic interaction. Inhibits endothelial cell migration and promotes endothelial tube formation via homotypic interactions. Required for normal organization of the lymph vessel network. Required for normal hematopoietic stem cell engraftment in the bone marrow. Plays a role in hematopoiesis; required for normal numbers of hematopoietic stem cells in bone marrow. Promotes in vitro osteoblast proliferation and differentiation (By similarity). Promotes neurite extension, axon growth and axon guidance; axons grow preferentially on surfaces that contain ALCAM (By similarity). Mediates outgrowth and pathfinding for retinal ganglion cell axons (By similarity).
Subcellular Location Cell membrane, Single-pass type I membrane protein, Cell projection, axon, Cell projection, dendrite
Tissue Specificity Expressed during axonogenesis in a subset of developing sensory and motor neurons that fasciculate with each other in the central nervous system (PubMed:8089660). Expressed in the retinotectal system of both embryos and adults, with expression in all reti
Database Links

KEGG: dre:30194

STRING: 7955.ENSDARP00000090957

UniGene: Dr.20912

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