Product Details

Full Product Name

Rabbit anti-Drosophila melanogaster (Fruit fly) Cad99C Polyclonal antibody

Uniprot No.

Q9VAF5

Target Names

Cad99C

Alternative Names

Cad99C antibody; CG31009Cadherin-99C antibody

Raised in

Rabbit

Species Reactivity

Drosophila melanogaster (Fruit fly)

Immunogen

Recombinant Drosophila melanogaster (Fruit fly) Cad99C protein

Immunogen Species

Drosophila melanogaster (Fruit fly)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB (ensure identification of antigen)

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Value-added Deliverables

① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);

Quality Guarantee

① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;

Lead Time

Made-to-order (14-16 weeks)

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Target Background

Function

Cadherin that functions in epithelial morphogenesis and the intestine epithelial immune response. Essential for female fertility. Regulates the length and organization of apical microvilli in developing follicle cells and salivary glands. Function in the follicle cell is essential for egg development as the microvilli secrete eggshell material such as the vitelline membrane. Acts at least in part by regulating the recruitment of the myosin ck to the follicle cell microvilli. Also required to regulate cell rearrangements during salivary tube elongation, possibly by modulating cellular adhesion between the apical surface and apical extracellular matrix during epithelial tube elongation. May also function in cellular adhesion during the development of other tubular epithelia such as the trachea. Possibly functions as an apical membrane determinant which acts in apical membrane expansion during salivary and tracheal epithelial tube elongation. In salivary gland development, this function is independent of the other apical membrane determinants crb and sas. Essential downstream component of a hh-signaling pathway which regulates the Duox-dependent gut epithelial immune response to bacterial uracil; required for endosome formation in the enterocyte and activating norpA-dependent Ca2+ mobilization, which are essential steps in the Duox-dependent production of reactive oxygen species (ROS) in response to intestinal bacterial infection.

Gene References into Functions

Cad99C is required to regulate cell rearrangement during salivary tube elongation. PMID: 24718992
Hedgehog-regulated transcription factor induces high-level expression of Cad99C. PMID: 15708564
Cad99C as a critical regulator of microvillus length, the first example of a transmembrane protein that is involved in this process. PMID: 16260500

Subcellular Location

Apical cell membrane; Single-pass type I membrane protein. Endosome membrane; Single-pass type I membrane protein. Cell projection, microvillus membrane; Single-pass type I membrane protein.

Database Links

KEGG: dme:Dmel_CG31009

STRING: 7227.FBpp0292214

UniGene: Dm.4517

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Cad99C Antibody

Product Details

Customer Reviews and Q&A

Target Background