clp-1 Antibody

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Code	CSB-PA335920XA01CXY
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Product Details

Full Product Name

Rabbit anti-Caenorhabditis elegans clp-1 Polyclonal antibody

Uniprot No.

P34308

Target Names

clp-1

Alternative Names

clp-1 antibody; C06G4.2Calpain clp-1 antibody; EC 3.4.22.- antibody

Raised in

Rabbit

Species Reactivity

Caenorhabditis elegans

Immunogen

Recombinant Caenorhabditis elegans clp-1 protein

Immunogen Species

Caenorhabditis elegans

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB (ensure identification of antigen)

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Value-added Deliverables

① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);

Quality Guarantee

① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;

Lead Time

Made-to-order (14-16 weeks)

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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Target Background

Function

Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates. Required for assembly and maintenance of integrin attachment complexes which are essential for maintenance of adult muscle. Proteolytic activity is activated in response to increased intracellular Ca(2+) levels during cell degeneration and promotes necrotic cell death.

Gene References into Functions

this study reports crystal structures of Clp1 from Caenorhabditis elegans (ceClp1) in a number of nucleotide- and RNA-bound states along the reaction pathway. PMID: 24813946
our analyses highlight the roles of calcium dysregulation and CLP-1 in muscle myopathies and suggest that the atypical calpains could retain conserved PMID: 22479198

Subcellular Location

Cytoplasm, myofibril, sarcomere, M line. Cytoplasm, myofibril, sarcomere.

Protein Families

Peptidase C2 family

Tissue Specificity

Expressed in muscle and neuronal tissues. Expressed in the ventral and dorsal nerve cord, intestinal and hypodermal tissues.

Database Links

KEGG: cel:CELE_C06G4.2

STRING: 6239.C06G4.2a.2

UniGene: Cel.17311

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Email: [email protected]
Distributors Worldwide

Service

Phage Display Service

Antibody Service

Protein Service

Gene Synthesis Service

Oligo Synthesis Service

Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Call us

301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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clp-1 Antibody

Product Details

Related Products

Customer Reviews and Q&A

Target Background