CAN1 Antibody

Datasheet

Code	CSB-PA255256XA01DOA
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Product Details
Customer Reviews and Q&A
Target Background

Product Details

Full Product Name

Rabbit anti-Arabidopsis thaliana (Mouse-ear cress) CAN1 Polyclonal antibody

Uniprot No.

F4IZC5

Target Names

CAN1

Alternative Names

CAN1 antibody; CAN antibody; At3g56170 antibody; F18O21.130Staphylococcal-like nuclease CAN1 antibody; EC 3.1.31.- antibody; Calcium-dependent nuclease 1 antibody; AtCAN1 antibody; Ca(2+)-dependent nuclease 1 antibody

Raised in

Rabbit

Species Reactivity

Arabidopsis thaliana

Immunogen

Recombinant Arabidopsis thaliana CAN1 protein

Immunogen Species

Arabidopsis thaliana (Mouse-ear cress)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB (ensure identification of antigen)

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Value-added Deliverables

① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);

Quality Guarantee

① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;

Lead Time

Made-to-order (14-16 weeks)

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

Enzyme that catalyzes the hydrolysis of both DNA and RNA at the 5' position of the phosphodiester bond. Possesses activity toward the single-stranded DNA, double-stranded DNA and RNA. May be involved in genomic DNA degradation during programmed cell death.

Gene References into Functions

Two Arabidopsis staphylococcal-like nucleases, named CAN1 and CAN2, are anchored to the cell membrane via N-terminal myristoylation and palmitoylation modifications.[CAN1] PMID: 23102437
AtCaN2, a Ca(2+)-dependent nuclease in Arabidopsis, is transcribed in senescent leaves and stems and interacts with an Arabidopsis cystatin (AtCYSb) in a yeast two-hybrid screen. PMID: 24076026
The protein encoded by AT3G56170 (CAN or CAN1) is a Ca2+-dependent and Zn2+-sensitive, plasma membrane nuclease which degrades ssDNA, dsDNA and RNA at neutral pH. This protein possesses a hybrid structure of its catalytic domain consisting of staphylococcal nuclease-like and tRNA synthetase anticodon binding-like motifs. Expression of CAN1 nuclease correlates with different forms of plant programmed cell death. PMID: 23102437

Subcellular Location

Cell membrane; Lipid-anchor.

Protein Families

Thermonuclease family

Database Links

KEGG: ath:AT3G56170

STRING: 3702.AT3G56170.1

UniGene: At.21067

Promotions

Email: [email protected]
Distributors Worldwide

Service

Phage Display Service

Antibody Service

Protein Service

Gene Synthesis Service

Oligo Synthesis Service

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Call us

301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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