CNB1 Antibody

Datasheet

Code	CSB-PA147281XA01SVG
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Product Details
Customer Reviews and Q&A
Target Background

Product Details

Full Product Name

Rabbit anti-Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) CNB1 Polyclonal antibody

Uniprot No.

P25296

Target Names

CNB1

Alternative Names

CNB1 antibody; YCN2 antibody; YCNB antibody; YKL190WCalcineurin subunit B antibody; Calcineurin regulatory subunit antibody; Protein phosphatase 2B regulatory subunit antibody

Raised in

Rabbit

Species Reactivity

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)

Immunogen

Recombinant Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) CNB1 protein

Immunogen Species

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB (ensure identification of antigen)

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Value-added Deliverables

① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);

Quality Guarantee

① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;

Lead Time

Made-to-order (14-16 weeks)

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

Regulatory subunit of calcineurin, a calcium-dependent, calmodulin stimulated protein phosphatase. Confers calcium sensitivity.

Gene References into Functions

Results reveal that EF1, EF2, and EF3 of CNB1 stimulate phosphatase activity independent of known conformational changes induced upon Ca2+ binding that lead to calmodulin binding and relief of bipartite auto-inhibition mediated by C-terminus of CNA. Also, the study indicates that distinct Cnb1 EF hand domains differentially affect calcineurin function, and that EF4 is not essential despite conservation across taxa. PMID: 29735720
The regulatory component of calcineurin, Cnb1, is essential for cell survival under compressive mechanical stress. PMID: 29196524
Hsp90 prevented the death of calcineurin- and Cmk2-deficient cells. PMID: 18806210

Protein Families

Calcineurin regulatory subunit family

Database Links

KEGG: sce:YKL190W

STRING: 4932.YKL190W

Promotions

Email: [email protected]
Distributors Worldwide

Service

Phage Display Service

Antibody Service

Protein Service

Gene Synthesis Service

Oligo Synthesis Service

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Call us

301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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