CASC3 Antibody

Datasheet
Code CSB-PA624752XA01DIL
Product Type Polyclonal Antibody
Uniprot No. Q1ECZ4
Delivery Make-to-order
Immunogen Recombinant Danio rerio (Zebrafish) (Brachydanio rerio) CASC3 protein
Raised in Rabbit
Species Reactivity Danio rerio (Zebrafish) (Brachydanio rerio)
Tested Applications ELISA, WB (ensure identification of antigen)
Form Liquid
Conjugate Non-conjugate
Storage Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Purification Method Protein A/G
Isotype IgG
Clonality Polyclonal
Alias Protein CASC3 (Cancer susceptibility candidate gene 3 protein homolog) (Metastatic lymph node protein 51 homolog) (DrMLN51) (Protein MLN 51 homolog) casc3 mln51
Immunogen Species Danio rerio (Zebrafish) (Brachydanio rerio)
Protocols ELISA Protocol
Gene Names casc3
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. The EJC marks the position of the exon-exon junction in the mature mRNA for the gene expression machinery and the core components remain bound to spliced mRNAs throughout all stages of mRNA metabolism thereby influencing downstream processes including nuclear mRNA export, subcellular mRNA localization, translation efficiency and nonsense-mediated mRNA decay (NMD). Binds spliced mRNA in sequence-independent manner, 20-24 nucleotides upstream of mRNA exon-exon junctions (By similarity).
Subcellular Location Cytoplasm, Cytoplasm, perinuclear region, Nucleus, Nucleus speckle, Cytoplasm, Stress granule, Cytoplasm, Cytoplasmic ribonucleoprotein granule, Cell projection, dendrite
Protein Families CASC3 family
Database Links

KEGG: dre:403025

STRING: 7955.ENSDARP00000040064

UniGene: Dr.80222

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