cacn-1 Antibody

Code CSB-PA908050XA01CXY
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Product Details

Full Product Name
Rabbit anti-Caenorhabditis elegans cacn-1 Polyclonal antibody
Uniprot No.
Target Names
cacn-1
Alternative Names
cacn-1 antibody; W03H9.4 antibody; Cactin antibody
Raised in
Rabbit
Species Reactivity
Caenorhabditis elegans
Immunogen
Recombinant Caenorhabditis elegans cacn-1 protein
Immunogen Species
Caenorhabditis elegans
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)
Usage
For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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Target Background

Function
Plays a role during early embryonic development. Required for the distal tip cell migration at the end of larval development and for gonad morphogenesis.
Gene References into Functions
  1. CACN-1 is needed in the soma for proper germ line development and maturation. When CACN-1 is depleted, sheath cells are absent and/or abnormal. CACN-1 is part of a protein network that influences somatic gonad development and function through alternative splicing or post-transcriptional gene regulation. PMID: 27046631
  2. RNAi depletion experiments and analysis of the hypomorphic allele cacn-1 indicate that CACN-1 is required during distal tip cells migration for proper pathfinding and for cessation of distal tip cells migration at the end of larval morphogenesis. PMID: 20188721
Subcellular Location
Nucleus. Cytoplasm.
Protein Families
CACTIN family
Tissue Specificity
Expressed in pharynx, intestine, vulva and spermatheca (at protein level).
Database Links

KEGG: cel:CELE_W03H9.4

STRING: 6239.W03H9.4a

UniGene: Cel.7464

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