Cp1 Antibody

Code CSB-PA822041XA01DLU
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Product Details

Full Product Name
Rabbit anti-Drosophila melanogaster (Fruit fly) Cp1 Polyclonal antibody
Uniprot No.
Target Names
Cp1
Alternative Names
Cp1 antibody; fs(2)50Ca antibody; CG6692Cathepsin L antibody; EC 3.4.22.15 antibody; Cysteine proteinase 1) [Cleaved into: Cathepsin L heavy chain; Cathepsin L light chain] antibody
Raised in
Rabbit
Species Reactivity
Drosophila melanogaster (Fruit fly)
Immunogen
Recombinant Drosophila melanogaster (Fruit fly) Cp1 protein
Immunogen Species
Drosophila melanogaster (Fruit fly)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
Important for the overall degradation of proteins in lysosomes. Essential for adult male and female fertility. May play a role in digestion.
Gene References into Functions
  1. Data show that cysteine proteinase 1 (CP1) is expressed in air sac primordium (ASP) and knockdown of CP1 results in suppression of migratory and invasive behavior observed during ASP development. PMID: 26341534
  2. Data show the models of the tertiary structures of cathepsin L constructed by using homology modeling methods. PMID: 23256878
  3. Premature activation of the effector caspase, dcp1, resulted in a disappearance of filamentous actin, rather than the formation of actin bundles, suggesting that dcp-1 activity must be restrained in late oogenesis. PMID: 12885559
  4. Drosophila decapping protein 1, dDcp1, is a posterior group gene required for the transport of osk mRNA. PMID: 16678775
Subcellular Location
Lysosome.
Protein Families
Peptidase C1 family
Tissue Specificity
In the embryo, predominantly expressed in the midgut. Also expressed in larval alimentary organs such as salivary gland and midgut including gastric caeca.
Database Links

KEGG: dme:Dmel_CG6692

STRING: 7227.FBpp0086719

UniGene: Dm.7400

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