Cavin1 Antibody

1. The authors show here in mature adipocytes, ribosomal transcription can be acutely regulated in response to metabolic challenges. This acute response is mediated by PTRF (polymerase I transcription and release factor, also known as cavin-1), which has previously been shown to play a critical role in caveolae formation. PMID: 27528195
2. The current analyses reveal roles for cavin-1 and related proteins in governing myocardial contractile function and compliance, coronary and cardiac responses to mechanical and ischaemic stressors, and membrane permeability/fragility PMID: 28343262
3. acetylated cavin-1 preferentially interacted with hormone-sensitive lipase and recruited it to the caveolae, thereby promoting lipolysis. PMID: 28559430
4. these results suggested that the membrane dynamics in cell migration is affected by caveolae associated PTRF/cavin-1. PMID: 25514038
5. study demonstrates a critical role of cavin-1 in vascular structure and function, but the influences on arterial resistance cancel each other such that arterial blood pressure remains unaltered in homeostatic conditions PMID: 24658465
6. lipid mobilization in cultured adipocytes to induce lipid droplet shrinkage led to biphasic response of cavin-1 with ultimate loss of expression of cavin-1 by protein degradation. PMID: 24969108
7. A Western-type diet in apo-E2 knock-in mice produced 3 groups of obese mice with PTRF expression correlating with glucose tolerance: normal, hyperinsulinemic glucose-tolerant, or impaired. PTRF compromised adipocyte differentiation of 3T3-L1 cells. PMID: 24812087
8. Adipocytes from cavin-1-null mice are markedly dysfunctional exhibiting decreased insulin-dependent glucose uptake, fatty acid uptake, and lipolysis. PMID: 24509860
9. PTRF is a crucial regulator of TLR4 signaling in the development of sepsis. PMID: 23908488
10. an important role for Cavin1 in lung homeostasis PMID: 23634221
11. Cavin-1 is critical for detrusor caveolae and for overall contractility and structure of the urinary bladder. PMID: 22643325
12. Cavin-1 modulates cellular polarization, and the subcellular localization of Rac1 and caveolin-1 in migrating cells as well as PKCalpha caveola recruitment. PMID: 22912783
13. Double-immunogold labeling showed that the caveolae-shaping molecule PTRF/cavin 1 behaved similarly and that syndapin II and PTRF/cavin 1 colocalized. PMID: 22718246
14. membrane-delimited interaction between MG53 and PTRF contributes to initiation of cell membrane repair PMID: 21343302
15. Our study is the first direct demonstration for a novel adipose tissue-specific function of PTRF as a mediator of lipolysis and also shows that phosphorylation of PTRF is required for efficient fat mobilization. PMID: 21282370
16. We conclude that PTRF-Cavin is required for caveola formation and sequestration of mobile caveolin into immobile caveolae. PMID: 18191225

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KEGG: mmu:19285

STRING: 10090.ENSMUSP00000058321

UniGene: Mm.21864