CCDC65 Antibody

Code CSB-PA816904XA01HU
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) CCDC65 Polyclonal antibody
Uniprot No.
Target Names
CCDC65
Alternative Names
CCDC65 antibody; DRC2Dynein regulatory complex subunit 2 antibody; Coiled-coil domain-containing protein 65 antibody; Testis development protein NYD-SP28 antibody
Raised in
Rabbit
Species Reactivity
Homo sapiens (Human)
Immunogen
Recombinant Homo sapiens (Human) CCDC65 protein
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (14-16 weeks)

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Target Background

Function
Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes. Plays a critical role in the assembly of N-DRC and also stabilizes the assembly of multiple inner dynein arms and radial spokes. Coassembles with DRC1 to form a central scaffold needed for assembly of the N-DRC and its attachment to the outer doublet microtubules.
Gene References into Functions
  1. Mutation in CCDC65, a nexin-dynein regulatory complex member, resulted in a frameshift mutation and PCD PMID: 23991085
  2. NYD-SP28, a sperm tail protein, was cloned and characterized. PMID: 17089017
Involvement in disease
Ciliary dyskinesia, primary, 27 (CILD27)
Subcellular Location
Cytoplasm, cytoskeleton, flagellum basal body. Cell projection, cilium, flagellum. Cytoplasm, cytoskeleton, flagellum axoneme.
Protein Families
DRC2 family
Tissue Specificity
Highly expressed in adult testis, in spermatocytes and spermatids. Also observed in spermatogonia. Not detected in Leydig cells, nor in fetal testis (at protein level).
Database Links

HGNC: 29937

OMIM: 611088

KEGG: hsa:85478

STRING: 9606.ENSP00000312706

UniGene: Hs.512805

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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